| Glycomics See AlsoDescriptionA group of enzymes with the general formula cmp-n-acetylneuraminate:acceptor n-acetylneuraminyl transferase. They catalyze the transfer of n-acetylneuraminic acid from cmp-n-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. Defects in sialyltransferase activity are an important component of what are termed 'aberrant forms of glycosylation' that are often seen in malignant tissue. Certain saponins? found in plants and legumes, called soyasaponins are potent inhibitors of sialyltransferase activity. Nomenclature| Approved Symbol | Aliases | Approved Name | | SIAT1 | CD75,ST6Gal I | sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase) | | SIAT2 | may be same as SIAT4 | sialyltransferase 2 (monosialoganglioside sialyltransferase) | | SIAT3 | ST6GalNAc I | (no human sequence as yet) | | SIAT4A | ST3O, SIATFL, ST3GalA.1, ST3Gal I | sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase) | | SIAT4B | ST3Gal IIST3GalA.2 | sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase) | | SIAT4C | CGS23, SIAT4, NANTA3, ST3Gal IV, STZ, SAT3 | sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase) | | SIAT5 | * | sialyltransferase 5 (galactosyldiacylglycerol alpha 2,3-sialyltransferase) | | SIAT6 | ST3Gal III | sialyltransferase 6 (N-acetyllactosaminide alpha 2,3-sialyltransferase) | | SIAT7 | ST6GalNAc II, III, IV?SThM | sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6- sialyltransferase) | | SIAT7 | ST6GALNAC III | sialyltransferase 7C | | SIAT7D | ST6GALNACIV,ST6GALNAC4, SIAT3C | sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3- beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) | | SIAT7E> | MGC3184, ST6GalNAcV | sialyltransferase 7E | | SIAT8A | ST8Sia I | sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase,GD3 synthase) | | SIAT8B | ST8Sia II, STX | sialyltransferase 8B (alpha-2, 8-sialytransferase) | | SIAT8C | ST8Sia III | sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase) | | SIAT8D | ST8Sia IV, PST | sialyltransferase 8D (alpha-2, 8-polysialytransferase) | | SIAT8E | ST8Sia V | sialyltransferase 8E (alpha-2, 8-polysialytransferase) | | SIAT9 | ST3GalV | sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase;GM3 synthase) | | SIATL | - | sialyltransferase-like |
Genebase and protein links| Approved Name | Chromosome Location | EC number | Sequence Acc. | SWISS-PROT | OMIM Number | | sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase) | 3q27-q28 | 2.4.99.1 | X62822, X17247, X54363 | P15907 | 109675 | | sialyltransferase 2 (monosialoganglioside sialyltransferase) | * | 2.4.99.2 | * | * | * | | (no human sequence as yet) | * | 2.4.99.3 | * | * | * | | sialyltransferase 4A (beta-galactoside alpha- 2,3-sialyltransferase) | 8 | 2.4.99.4 | L29555, L13972, AF059321 | Q11201 | * | | sialyltransferase 4B (beta-galactoside alpha- 2,3-sialyltransferase) | 1p34-p21 | 2.4.99.4 | U63090, X96667 | * | * | | sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase) | 11q23-q24 | 2.4.99.4 | X74570, L23767 | Q11206 | 104240 | | sialyltransferase 5 (galactosyldiacylglycerol alpha 2,3-sialyltransferase) | * | 2.4.99.5 | * | * | * | | sialyltransferase 6 (N-acetyllactosaminide alpha 2,3-sialyltransferase) | * | 2.4.99.6 | L23768 | Q11203 | * | | sialyltransferase 7 ((alpha-N-acetylneuraminyl- 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6- sialyltransferase) | 17 | 2.4.99.7 | ??U14550 | * | * | | sialyltransferase 7C | 1 | * | AK091215 | * | * | | sialyltransferase 7D ((alpha-N-acetylneuraminyl- 2,3- beta-galactosyl-1,3) -N-acetyl galactosaminide alpha-2,6-sialyltransferase) | 9q34 | * | L32867 | * | * | | sialyltransferase 7E | 1p31.1 | * | AK095758 | * | * | | sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) | 12 | 2.4.99.8 | L32867, D26360, L43494, X77922 | Q92185 | 601123 | | sialyltransferase 8B (alpha-2, 8-sialytransferase) | 15q26 | 2.4.99.- | U82762,U33551 | Q92186 | 602546 | | sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase) | 18 | * | AF004668 | * | * | | sialyltransferase 8D (alpha-2, 8-polysialytransferase) | 5q21 | 2.4.99.- | L41680 | Q92187 | 602547 | | sialyltransferase 8E (alpha-2, 8-polysialytransferase) | 18 | * | U91641 | * | * | | sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) | * | 2.4.99.9 | AF105026 | * | * | | Gal beta 1,4GlcNAc alpha-2,3-sialyltransferase | * | * | AB022918 | * | * | | sialyltransferase-like 1 | -* | * | | * | * |
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