C O N T E N T S
Soyasaponins are bioactive compounds found in many legumes. Results from in vitro fermentation suggested that colonic microflora readily hydrolyzed the soyasaponins to [Aglycone? aglycones].
Soyasaponins appear to be significant inhibitors of sialyltransferase, which may indicate a significant role in cancer chemotherapeutics and prevention.
These observations suggest that the soyasaponins may be an important dietary chemopreventive agent against colon cancer, after alteration by microflora.(1)
Soyasaponins appear to be hepatoprotective. (2, 3 )
Although soyasaponins are bioactive, there is evidence of rather limited intestinal absorption. (6) However, since they are typically found in lectin-containing legumes, and [Lectins, induced changes in intestinal permeability? lectins induce increased gut permeability], it could be conjectures that soyasaponin isolates may not be as easily assimilated as instead when present in the intact whole food.
Soyasaponin I, a potent and specific sialyltransferase inhibitor
Biochem Biophys Res Commun. 2001 Jun 8;284(2):466-9. Wu CY, Hsu CC, Chen ST, Tsai YC. Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
Human fecal metabolism of soyasaponin I
J Agric Food Chem. 2004 May 5;52(9):2689-96. Hu J, Zheng YL, Hyde W, Hendrich S, Murphy PA.
Department of Food Science and Human Nutrition, and College of Veterinary Medicine, Iowa State University, 2312 Food Science Building, Ames, Iowa 50011, USA.
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids
Gynecol Oncol. 2005 Feb;96(2):415-22. Hsu CC, Lin TW, Chang WW, Wu CY, Lo WH, Wang PH, Tsai YC. Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells
Biochem Biophys Res Commun. 2006 Mar 10;341(2):614-9. Epub 2006 Jan 13. Chang WW, Yu CY, Lin TW, Wang PH, Tsai YC.
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan, ROC.
1. Gurfinkel DM, Rao AV. Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity. Nutr Cancer. 2003;47(1):24-33.
2. Kinjo J, Hirakawa T, Tsuchihashi R, Nagao T, Okawa M, Nohara T, Okabe H. Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells. Biol Pharm Bull. 2003 Sep;26(9):1357-60
3. Kinjo J, Imagire M, Udayama M, Arao T, Nohara T. Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone. Planta Med. 1998 Apr;64(3):233-6
4. Mahato SB. Triterpenoid saponins from Medicago hispida. Phytochemistry. 1991;30(10):3389-93
5. Oleszek W, Stochmal A. Triterpene saponins and flavonoids in the seeds of Trifolium species. Phytochemistry. 2002 Sep;61(2):165-70
6. Hu J, Reddy MB, Hendrich S, Murphy PA. Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women. J Nutr. 2004 Aug;134(8):1867-73
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