dadamowiki

A wikipedia of Dr. D'Adamo's research



References

Effect of herbal melanin on IL-8: A possible role of Toll-like receptor 4 (TLR4)

Biochem Biophys Res Commun. 2006 Apr 28;

El-Obeid A, Hassib A, Ponten F, Westermark B.

  • The production of IL-8 can be induced by LPS via TLR4 signaling pathway. In this study, we tested the effect of a herbal melanin (HM) extract, from black cumin seeds (Nigella sativa L.), on IL-8 production. We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells. Both HM and LPS induced IL-8 mRNA expression and protein production in THP-1 and PBMCs. On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production. We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14. Melanin extracted from N. sativa L. mimics the action of LPS in the induction of IL-8 by PBMC and the other used cell lines. Our results suggest that HM may share a signaling pathway with LPS that involves TLR4.
SPOTLIGHT

COMPLETE BLOOD TYPE ENCYCLOPEDIA


The Complete Blood Type Encyclopedia is the essential desk reference for Dr. D'Adamo's work. This is the first book to draw on the thousands of medical studies proving the connection between blood type and disease.

Click to learn more

Click the Play button to hear to Dr. Peter J. D'Adamo discuss .



The statements made on our websites have not been evaluated by the FDA (U.S. Food & Drug Administration).
Our products and services are not intended to diagnose, cure or prevent any disease. If a condition persists, please contact your physician.
Copyright © 2015-2020, Hoop-A-Joop, LLC, Inc. All Rights Reserved.     Log In