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BTD Forums  /  Supp Right For Your Type  /  Rhodiola advised, but is it an MAOI?
Posted by: 15353 (Guest), Tuesday, July 26, 2011, 9:50pm
I'm a type-O, probably non-secretor, but I'm not sure yet.

DrD recommends rhodiola rosea to type-Os as an adaptogen. He also recommends that type-Os avoid taking MAOIs. But I had heard that rhodiola rosea acts as an MAOI. I checked on and found a study that showed this.

So, does anyone have a commend on this contradiction in DrD's recommendations?

I'm interested because I seem to be sensitive to tyramine, which is metabolized by MAO. I am wary of foods that contain tyramine as well as anything that might inhibit MAO (especially since type-Os have relatively low MAO activity according to DrD).


Posted by: Lloyd, Tuesday, July 26, 2011, 10:04pm; Reply: 1
The wikipedia article on MAOI's lists a number of herbals including rhodiola, ginkgo, tumeric (curcumin), yerba and eleuthero. Not to mention alkaloids found in coffee!  :o

How much you get from any of these is another matter. If you are on an MAOI it might be important.

Individuality says that there may be a few that are sensitive enough that it matters for them, but not for the larger group.
Posted by: Lloyd, Tuesday, July 26, 2011, 10:08pm; Reply: 2
From the page on rhodiola:

Quoted Text
Rhodiola rosea may be effective for improving mood and alleviating depression. Pilot studies on human subjects[2][3][4] showed that it improves physical and mental performance, and may reduce fatigue.

Rhodiola rosea's effects are potentially mediated by changes in serotonin and dopamine levels due to monoamine oxidase inhibition and its influence on opioid peptides such as beta-endorphin,[5] although these specific neurochemical mechanisms have not been clearly documented with scientific studies.

Rhodiola is included among a class of plant derivatives called adaptogens which differ from chemical stimulants, such as nicotine, and do not have the same physiological effects.
Posted by: 15353 (Guest), Tuesday, July 26, 2011, 10:27pm; Reply: 3
Here's the study I found on pubmed

It makes sense that different individuals would be more or less sensitive, and I can see how in vitro MAOI activity might not correlate perfectly with what happens in the gut.

Thanks for the replies!
Posted by: Andrea AWsec, Tuesday, July 26, 2011, 11:51pm; Reply: 4
Why not give it a try and see how you feel? you can always stop it.
Posted by: 15353 (Guest), Wednesday, July 27, 2011, 12:13am; Reply: 5
Well I was taking it up until my most recent episodes. I can't be sure that the rhodiola made a difference, but I am pretty sure that tyramines are behind the experiences I've had. I'm going to be extra careful for a while in the hopes that following LR4YT will help me become one of those healthy people with a better tolerance for avoids!
Posted by: ruthiegirl, Wednesday, July 27, 2011, 12:36am; Reply: 6
There is a difference in the actions of natural herbs and pharmaceuticals. Just because MAOIs are contra-indicated for most Os doesn't mean that an herb with multiple functions, including slight MAOI, will have the same effect.

For you personally, with your unique medical history, rhodiola is either going to be extremely helpful and healing, or harmful for you. If it were me, I'd avoid it until I knew more. I don't take chances with my mental health!!

I can tell you from personal experience that avoiding wheat and innapropriate dairy are a HUGE boost to my mental health, along with making sure I get enough red meat and fish.
Posted by: snazzyshazz, Wednesday, July 27, 2011, 1:42am; Reply: 7
Hi Charlie, I am O+, non secretor (well, following non-secretor values, since I am actually Lewis double negative)and I have been taking rhodiola for some time now. I find it excellent! My depression doesn't seem to be exacerbated by it. In fact, my depression drastically improved after I began my swami program.
Posted by: 8717 (Guest), Wednesday, July 27, 2011, 3:33am; Reply: 8
Hi Charlie  ;D
Posted by: SquarePeg, Wednesday, July 27, 2011, 6:03pm; Reply: 9
I consider Rhodiola my "deserted island" supplement.  If I got stranded on a desert island, the one supplement I would absolutely not want to give up is Rhodiola Rosea.  But that's me.

Be sure to carefully search for and review errata on all the literature you're basing your decisions on, including the D'Adamo books.

Good luck.
Posted by: Symbi, Friday, July 29, 2011, 12:09am; Reply: 10
lol Squarepeg, wondered recently why desert islands are usually tropical then it twigged, deserted as in empty DOH!  ::) :D

My DH is O and we both tried Rhodiola (though it's an avoid for As I didn't realise).  I'm also sensitive to tyramines (maybe you're an Explorer too Charlie!).  It didn't seem to affect me that way much or it was just short lived and I avoid those foods anyway.  

What it did to for me and DH was put us in bed straight after taking the tablet and then wake up later wired.  It was Rhodiola rosea extract equiv. dry root 965mg maybe a big dose?

Here are some quotes from me before "MY DH tried a B vitamin with Rhodiola.  It made him very sleepy for a few hours and then stimulated.  So we tried it at night.  Not a good idea, he was drowsy during evening and then awake most of the night!  The next day he was more relaxed than usual (it's supposed to fight anxiety).  Maybe that was just lack of sleep hangover?"
you may like to read Jesi an O talks about it here too -

Here's a quote from when I tried it before but remember I'm an A:
"Recently I tried rhodiola and that had a funny aftertaste that I didn't enjoy.  (also my adrenals were burning didn't like the stimulation).  Knew that I should have checked on here rather than general websites - it's recommended for Os not As.  Guess As don't need help breaking down adrenalin.  DH could use it though.  I reckon it was breaking down into a bad metabolite in my bod?? "
Posted by: SquarePeg, Friday, July 29, 2011, 7:09pm; Reply: 11
965mg sounds like a huge amount.  I take the Pure Encapsulations capsule.  I don't have time to check, but I think it's only 100mg or 200mg.

Thanks for the links!
Posted by: ruthiegirl, Friday, July 29, 2011, 11:01pm; Reply: 12
I'm currently using a 400 mg capsule, but that's the whole herb, not a potent extract. I selected that one because it was free of any questionable additives. I knew it would be less potent, but for a daily supplement, sometimes smaller is better, and I always have the option of taking more than one if necessary.
Posted by: WadeWilson, Thursday, November 8, 2012, 11:02pm; Reply: 13
Hi symbi,

where does it say that rhodiola should be avoided for type A's? i'm interested in trying this, but curious as to why it might be an avoid
Posted by: Possum, Thursday, November 8, 2012, 11:52pm; Reply: 14
WadeWilson it might take Symbi a while to get back to you as she has not been well lately...
Hopefully someone else can answer that question for you?!
Posted by: deblynn3, Friday, November 9, 2012, 12:14am; Reply: 15
Of topic, sorry, but glad to hear from you, Symbi, sorry your not feeling well. I was just wondering why I hadn't seen you on the forum lately.  

Which of the Doc's formula have Rhodiola in them? Seems I remember at least one.  
Posted by: Amazone I., Friday, November 9, 2012, 9:46am; Reply: 16
charlie please remember...*artwork* is liable to determined circumstances ..... ;)(evil)(ondrugs)........... :X
Posted by: Eric, Friday, November 9, 2012, 5:29pm; Reply: 17
From what I understand, there are different kinds of MAO inhibition.  The MAO-I in St. John's Wort is different from that in Rhodiola.  Someone call me on this if I'm wrong.  I just know, anecdotally, that I'm extremely... like, ridiculously, sensitive to hormone balance.  And Rhodiola has done nothing but good, while St John's and other avoid substances wreck me.
Posted by: Lola, Saturday, November 10, 2012, 3:47am; Reply: 18
yes, to each their own
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