dadamowiki A wikipedia of Dr. D'Adamo's research

Subset of likely Type 2 diabetes genes

Nutrigenomics

See Also

• 19q13.3
• Blood groups and diabetes mellitus. A possible tool in the analysis of the hereditary background of diabetes mellitus
• ENPP1 (ectonucleotide pyrophosphatase-phosphodiesterase 1)
• Quantitative trait locus analysis
• Trp64Arg polymorphism, body composition, insulin resistance and bioimpedance (BIA)
• Trp64Arg polymorphism of the beta3-adrenergic receptor gene

Subset of Likely T2DM Candidate Genes ({{Kaput J. An introduction and overview of nutritional genomics: Application to type 2 diabetes and international nutrigenomics. In: From Kaput J and Rodriguex R. <u>Nutritional Genomics</u>. 2006 Wiley}})

Gene	Function	Chromosome	Reference
SLC2A1	GLUT1 glucose transporter	1p35-p31.3	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14527304&query_hl=5&itool=pubmed_docsum]
IRS	Insulin receptor substrates (IRS-1 has best evidence)	2q36'	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
CAPN10	Calpain 10	2q37.3'	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
PPARG	Peroxisome proliferators activated receptor y	3p25	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14527304&query_hl=5&itool=pubmed_docsum]
APMI	Adiponectin	3q27	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
PGC-1	Peroxisome proliferators activated receptor y	4p15.1	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
ADRBR2	B3-Adrenergic receptor	5q32-q34	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
ENPP1	Glycoprotein PC-1	6q22-q23	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
GCK	Glucokinase	7p15-p13	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14527304&query_hl=5&itool=pubmed_docsum]
ADRBR3	beta3-Adrenergic receptor	8p12-p11.2	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
KCNJIl	Potassium inward rectifier channel IC6.2	11p15.1	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
ABCC8	Sulfonylurea receptor	11p15.1	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14527304&query_hl=5&itool=pubmed_docsum]
VNTR-INS	Variable number tandem repeat in the insulin gene	11p15.5	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
FOXc2	Transcription factor	16q24.3	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
GCGR	Glucagon receptor	17q25	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14527304&query_hl=5&itool=pubmed_docsum]
LIPE	Hormone sensitive lipase	19q13.1-q13.2	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
GYSI	Glycogen synthase	19q13.3	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15041791&query_hl=3&itool=pubmed_docsum]
HNF4A	Hepatic nuclear factor 4a	20q12-q13.15	[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed]

References

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