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dadamowiki A wikipedia of Dr. D'Adamo's research |
Interleukin-8 (IL-8)
See AlsoDescription
Interleukin-8 (IL-8) IL-8 is an interleukin that acts as a chemokine for leukocytes and connective tissue cells. IL-8 is produced by monocytes, neutrophils, and NK cells and is acts as a homing defice for neutrophils, basophils and [T lymphocyte|T-cells.]]
Discussion
One of the first chemokines to be isolated; one of the C-X-C family (8 kD). Secreted by a variety of cells and potently chemokinetic and chemotactic for neutrophils and basophils but not monocytes. Receptor is G-protein coupled.
Members of the chemokine family fall mostly into two broad groups-CC chemokines (or β-chemokines) with two adjacent cysteines near the amino terminus of the protein, and CXC chemokines (or α-chemokines) in which the cysteines are separated by an amino acid. The two groups of chemokines act on different receptors. CC chemokines bind to CC chemokine receptors, of which nine have been discovered to date, designated CCR1-9. CXC chemokines bind to CXC chemokine receptors, of which five have been discovered to date, designated CXCR1-5. These receptors are expressed on the surface of different cell types. CXC chemokines which have a specific amino acid sequence (or motif) of Glutamic acid-Leucine-Arginine (or ELR for short) immediately before the first cysteine induce the migration of neutrophils. An example of this is interleukin-8 (IL-8) which induces neutrophils to leave the bloodstream and enter into the surrounding tissue.
Chronic hyperglycemia is an established risk factor for endothelial damage. It remains unclear, however, whether brief hyperglycemic episodes after acute stress alter the function of vascular endothelial cells in response to endotoxin. Hyperglycemic conditions enhance IL-8 production by vascular endothelial cells, and this response is augmented by LPS. Infections may foster neutrophil accumulation at injury sites. These results suggest that it is important to manage even short-term increases in blood glucose after acute stress.( {{Kinoshita K, Furukawa M, Ebihara T, Sakurai A, Noda A, Kitahata Y, Utagawa A, Tanjoh K.Acceleration of chemokine production from endothelial cells in response to lipopolysaccharide in hyperglycemic condition.Acta Neurochir Suppl. 2006;96:419-21.}} )
Abstracts Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer
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