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dadamowiki A wikipedia of Dr. D'Adamo's research |
Interleukin-6 (IL-6)
See Also- Cytokines
- Tumor Necrosis Factor (TNF)
- Toll-like receptors (TLRs)
- STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
Description
Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Additionally osteoblasts to stimulate osteoclast formation. Inhibitors of IL-6 (including estrogen) are used to treat postmenopausal osteoporosis. IL-6 is one of the most important mediators of fever and of the acute phase response. In the muscle and fatty tissue IL-6 stimulates energy mobilization which leads to increased body temperature. IL-6 can be secreted by macrophages in response to pathogen associated molecular patterns (PAMPs) binding the Toll-like Receptor (TLR) present on an active macrophage.
IL-6 is released in response to IL-1 and TNF-b ( {{Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer.
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