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Genetic polymorphisms in dietary xenobiotic metabolizing enzymes
C O N T E N T S
See AlsoDescription
| Gene | Polymorphic alleles | Effect on enzyme function |
| CYP1A1 | MspI (intron 7) | Unknown |
| CYP1A1 | Val/Ile (exon 7) | Unknown |
| CYP1B1 | M1 (Va1432Leu) | Unknown |
| CYP1B1 | M2 (Asn453Ser) | Unknown |
| NAT1 | *4 | Low activity (wild type) |
| NAT1 | *10 | High activity |
| NAT2 | *4 | High activity |
| NAT2 | 5A, *5B, *6A, *6B, *7A, 7B, *12A, *13, *13B | Low activity alleles |
| GSTA1 | Al*1 | High transcriptional activity |
| GSTA1 | Al*B | Low transcriptional activity |
| GSTM1 | Null allele | No activity |
| GSTT1 | Null allele | No activity |
| GSTP1 | Va1105 | High activity (wild type) |
| GSTP1 | Ile105 | Low activity |
| SULT1A1 | Arg213 | High activity (wild type) |
| SULT1A1 | His213 | Low activity |
| UGT1A1 | *1 | High transcriptional activity |
| UGT1A1 | *28 | Lower transcriptional activity |
| UGT1A1 | *33 | Lower transcriptional activity |
| UGT1A1 | *34 | Lower transcriptional activity |
| UGT1A6 | T181 + R184 | High activity |
| UGT1A6 | A181 + 5184 | Low activity |
Genetic polymorphisms in dietary xenobiotic metabolizing enzymes
Attribution
From: Nowell S and Kadlubar F. 'Cancer and gene variants in enzymes metabolizing dietary xenobiotics'. In: Nutritional Genomics, Edited by Flohe and Joost, copyright 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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