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dadamowiki A wikipedia of Dr. D'Adamo's research |
Apolipoprotein A-I (APOA1), Apolipoprotein A-4 (APOA4),
See AlsoDiscussion
Cardiovascular disease (CVD) risk is the result of complex interactions between genetic and environmental factors. During the past few decades, much attention has focused on plasma lipoproteins as CVD risk factors. The current evidence supports the concept that gene-environment interactions modulate plasma lipid concentrations and potentially CVD risk. The findings from studies examining gene-diet interactions and lipid metabolism have been highly promising. Several loci (i.e., APOA1, APOA4, APOE, and LIPC) are providing proof-of-concept for the potential application of genetics in the context of personalized nutritional recommendations for CVD prevention. ( {{Corella D, Ordovas JM.SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Annu Rev Nutr. 2005;25:341-90. }} )
APOA1- Gene name: APOA1
- Name: apolipoprotein A-I
- Chromosome: 11; Location: 11q23-q24
- Gene type: protein coding
- Organism: Homo sapiens
- Gene aliases: MGC117399
Summary
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
APOA4- Official Symbol: APOA4
- Name: apolipoprotein A-IV
- Chromosome: 11; Location: 11q23
- Gene type: protein coding
- Gene name: APOA4
- Gene description: apolipoprotein A-IV
- Organism: Homo sapiens
Summary
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
Abstracts Genetic interactions with diet influence the risk of cardiovascular disease
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