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'A-Like' tumor antigens
[[Pathology]] ====See Also==== * [[Aberrent glycosylation in malignant and pre-malignant states]] * [[Forssman . . . I(Ma) antigen, Lewis a antigen and monoclonal antibody-defined tumor-associated antigen CA 19-9 in . . . (A-like antigen) reactive with monoclonal anti-A antibody was also detected in cancer cells of blood . . .
16K - last updated 2006-06-30 17:45 UTC by PeterDAdamo
ABO bias in natural immunity
[[Serology]] ====See Also==== * [[Agglutination]] * [[Flocculation]] * [[Isohemagglutinin Titer]] * [[Isohemagglutinins]] . . . normal subjects show "naturally occurring" antibody to non-self ABO [[antigen|antigens.]] These . . . in group O, large amounts of "immune" [[IgG]] [[antibody]] may be produced. Almost thirty years ago, . . . Membrane bound monomeric IgM is the major antibody receptor used by B-lymphocytes to recognize . . . Technical Manual 10th ed. 1989. Method 4.3 "Antibody Titration". American Association of Blood . . .
18K - last updated 2006-05-11 15:54 UTC by PeterDAdamo
Aberrent glycosylation in malignant and pre-malignant states
[[Glycomics]] ====See Also==== * [['A-Like' tumor antigens]] * [[Thomsen-Friedenreich (T-Tn) antigen]] . . . glycopeptides. With the advent of monoclonal antibody technology in the late 1970s, investigators . . .
7K - last updated 2006-06-04 05:43 UTC by AlanGoldenberg
[[Lectinology]] ====See Also==== * [[Antibody]] * [[Flocculation]] * [[Lectins]] * [[Precipitin]] * [[Serology]] . . . the actions of an [[agglutinin]], such as an [[antibody]] or a lectin. Certain viruses and bacteria . . . clumping of particles. This is usually due to an antibody or other molecule binding with multiple particles, . . . or red blood cells, in the presence of an antibody. Because the clumping reaction occurs quickly . . .
4K - last updated 2006-07-11 05:39 UTC by AlanGoldenberg
[[Immunology]] ====See Also==== * [[Allergy]] * [[Allergy, ABO Blood Group and Secretor Status]] ====Description==== . . . stimulation by the circulating immune complex of antibody and allergen. Normally taken up by the liver, . . .
4K - last updated 2006-06-02 06:50 UTC by AlanGoldenberg
Alternate Complement Pathway
[[Serology]] ====See Also==== * [[Collectins]] * [[Complement System]] ====Description==== The complement . . . of these complement proteins with antigen-antibody complexes to activate the initial cleavage . . . cell surfaces in the absence of specific antigen-antibody complexes. This non-specific activation is . . .
4K - last updated 2006-11-27 18:19 UTC by ool-43560645.dyn.optonline.net
[[Serology]] ====Definition==== Also known as [[immunoglobulins]] (Ig), antibodies are specialized proteins . . .
1K - last updated 2007-04-06 03:00 UTC by DonStJohn
Antibody afinity and avidity
[[Serology]] ====See Also==== * [[Antibody]] * [[Antigen]] ====Affinity==== Antibody affinity is the . . . determinant and a single combining site on the antibody. It is the sum of the attractive and repulsive . . . determinant and the combining site of the antibody. Affinity is the equilibrium constant that . . . describes the Antigen-Antibody reaction. Most antibodies have a high affinity . . . a single antigenic determinant and an individual antibody combining site whereas avidity refers to the . . .
1K - last updated 2006-06-19 18:33 UTC by PeterDAdamo
[[Immunology]] ====See Also==== * [[Blood group antigen proteins (chart)]] * [[Antigen]] * [[ABO Antibodies]] . . . the fucose residue makes contact with the antibody binding site or stabilizes a particular conformation . . . but is not itself in contact with the antibody. The structures of most of the ABH and Lewis . . . precipitation of a blood-group substance with an antibody specific for a single determinant, and the . . .
21K - last updated 2006-06-30 16:34 UTC by PeterDAdamo
Celiac Disease (Sprue), ABO and Secretor Blood Types
[[Pathology]] ====See Also==== * [[The C282Y mutation may have been positively selected as it mitigates . . . In contrast with having too much of that [[antibody]], it is ten times more common in celiac patients . . . to have a lack of [[IgA]] (the protective antibody in mucus) than in the general population. . . .
9K - last updated 2007-01-19 21:51 UTC by DonStJohn
Duffy blood group system
[[Polymorphism]] ====See Also==== * [[Allele]] * [[Chemokines]] * [[Interleukin-8 (IL-8)]] FY Gene locus . . . the first example of anti-Fya. In 1951, the [[antibody]] to the antithetical [[antigen]], Fyb, was . . .
15K - last updated 2006-05-14 19:52 UTC by PeterDAdamo
Effect of photo-oxidation on isohemagglutinating antibodies
[[References]] ====EFFECT OF PHOTO-OXIDATION ON ISOHEMAGGLUTINATING ANTIBODIES ==== The Journal of Experimental . . . into inhibiting ("incomplete" or "blocking") antibody. Submitted on December 9, 1945 * [http://www.jem.org/cgi/reprint/83/3/221?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&author1=william+boyd&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT . . .
1K - last updated 2006-05-03 12:02 UTC by PeterDAdamo
[[Serology]] ====See Also==== * [[Precipitin]] * [[Agglutination]] * [[Immuno-diffusion]] * [[Radial . . . by a flocculent precipitate of antigen and antibody. It is typically produced through a technique . . . [[precipitin]] test, dilutions of antigen and antibody in aqueous solution are combined until a precipitation . . . an antigen out of solution using an antibody specific to that antigen. This process can . . . The Wassermann test is a complement-fixation antibody test for syphilis, named after the bacteriologist . . .
4K - last updated 2006-06-19 18:30 UTC by PeterDAdamo
[[Glycomics]] ====See Also==== * [[Thomsen-Friedenreich (T-Tn) antigen]] * [['A-Like' tumor antigens]] . . . procedures versus thin-layer chromatography/antibody overlay procedures. The function of this antigen . . .
5K - last updated 2006-06-13 07:15 UTC by AlanGoldenberg
[[Immunology]] ====See Also==== * [[Epitope]] * [[Antigen]] ====Description==== A compound, usually of . . . or cells, becomes immunogenic and induces antibody, which can bind the hapten alone in the absence . . . hapten may also be able to bind to the antibody, but it will usually not initiate an immune . . . by preventing the adduct from binding to the antibody. http://www.dadamo.com/wiki/hapten.jpg <i>Principle . . . there is a proliferation of B cells able to make antibody to the hapten adduct. After a second exposure . . .
3K - last updated 2006-06-19 12:36 UTC by PeterDAdamo
Helicobacter pylori infection, ABO and secretor blood groups
[[Pathology]] ====See Also==== * [[ABH Antigens]] * [[Adhesins]] * [[Cell Adhesion Molecules (CAMs)]] . . . lower IgG (H. pylori immunoglobulin G ([[IgG]]) antibody) immune response to H. pylori antigens as . . . a lower IgG (H. pylori immunoglobulin G (IgG) antibody) immune response to H. pylori antigens as . . .
11K - last updated 2006-06-29 11:59 UTC by TomGreenfield
[[Immunology]] ====Description==== The term 'humoral immunity' refers to any soluble factor found in . . . B-cells have a critical function: They are the antibody manufacturers. When an [[antigen]] is presented . . . B cells can produce large amounts of a specific antibody to the antigen. In order to appreciate what . . . look at what they make. To understand what an [[antibody]] is, we must first understand the significance . . . anything the immune system considers 'non-self.' Antibody either destroys the antigen directly, or coats . . .
3K - last updated 2006-04-19 20:56 UTC by ool-435621f6.dyn.optonline.net
[[Serology]] ====See also=== * [[Allergy]] * [[Allergy, ABO Blood Group and Secretor Status]] * [[Allergens, . . . ====Description==== Immunoglobulin E (IgE) is an antibody subclass (known as "isotypes"), found only . . . through control of B cell differentiation to antibody-secreting plasma cells is thought to involve . . .
6K - last updated 2006-05-12 09:24 UTC by PeterDAdamo
[[Serology]] ====See Also==== * [[Agglutination]] * [[ABO Antibodies]] ====Description==== IgM forms . . . activation. It is also a so-called "natural antibody": it is found in the serum without any evidence . . . Source] IgM accounts for about 10% of the total antibody pool in the body and is the predominant antibody . . . of the early immune response. IgM is the first antibody to be produced in response to infection since . . . it does not require "class switch" to another antibody class. IgM is the only class produced by the . . .
4K - last updated 2006-04-25 19:12 UTC by PeterDAdamo
Influenza, ABO, MN and other polymorphisms
[[Pathology]] ====See Also==== * [[Neuraminidase ]] The influenza virus may be the most dangerous virus . . . ability to generate a quick and substantial antibody response against influenza type A(H1N1) and . . . Tissue Antigens 1980 Oct;16(4):310-3}}) Their antibody response against influenza B is not quite . . . has a relatively poor ability to generate high antibody levels against any of the influenza viruses. . . . Blood group B: Reasonable ability to generate an antibody response against influenza A(H1N1). Slowest . . .
8K - last updated 2006-05-04 23:22 UTC by PeterDAdamo
Inhibitory activity of blood group antigens M and N in inhibition of virus influenza hemagglutination
[[References]] ====Inhibitory activity of blood group antigens M and N in inhibition of virus influenza . . . differences of average geomaterical levels of antibody titers. Enzymatically derived red cells by . . .
3K - last updated 2006-06-10 17:54 UTC by TomGreenfield
[[Immunology]] ====See Also==== * [[Cytokines]] * [[Tumor Necrosis Factor (TNF)]] * [[Toll-like receptors . . . drug in this field is the anti IL- 6 receptor antibody (MRA), used as one of new therapeutic approaches . . .
5K - last updated 2006-05-31 18:11 UTC by PeterDAdamo
Kell Blood Group
[[Polymorphism]] ====See Also==== * [[Allele]] * [[Antigen]] * [[Blood group systems]] * [[Glycoproteins]] . . . ====Historical aspects==== The first Kell system antibody was described in 1946, shortly after the implementation . . . who lack a specific Kell antigen may develop [[antibody|antibodies]] against Kell antigens when transfused . . . anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red . . .
17K - last updated 2006-07-21 10:45 UTC by TomGreenfield
[[Glycomics]] ====See Also==== * [[Mucin]] * [[Aberrent glycosylation in malignant and pre-malignant . . . to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, . . .
4K - last updated 2006-05-03 22:50 UTC by PeterDAdamo
Mucosal Immune Response
[[Immunology]] ====Description==== <div class="quote"> [http://www.dadamo.com/knowbase/immunity/immunity5.htm . . . Shiga bacillus infection regardless of the serum antibody level. Davis, in 1922, showed that fecal antibody . . . of patients with bacillary dysentery before the antibody was found in serum. The discovery of the immunoglobulin . . .
2K - last updated 2006-04-17 19:17 UTC by dhcp64-134-129-168.wbt.phx.wayport.net
[[Biochemistry]] ====See Also==== * [[Argininosuccinate synthase]] * [[Arginine]] * [[Endothelial dysfunction]] . . . this must be the result of a lack of "anti-B antibody" which perhaps assists the NO in working. . . .
9K - last updated 2006-08-03 07:57 UTC by AlanGoldenberg
On the mechanism of specific precipitation
[[References]] ====ON THE MECHANISM OF SPECIFIC PRECIPITATION==== [[William Boyd|William C. Boyd Ph.D.]] . . . by mutual neutralization of polar groups of antibody and antigen (or hapten) and mechanical blocking . . . polar groups of closely neighboring molecules of antibody, of the solubility of the complex below the . . . the amount of steric hindrance exerted by one antibody molecule on another. No hypothesis is offered . . .
2K - last updated 2006-05-03 12:18 UTC by PeterDAdamo
[[Immunology]] ====See Also==== * [[Mannan-binding lectin (MBL)]] * [[Collectin]] * [[Macrophage]] * . . . process of opsonization, antigens are bound by antibody and/or complement molecules. Phagocytic cells . . . to phagocytes. Examples of opsonins include IgG antibody and the C3b molecule of the complement system. . . . Examples of opsonin molecules include the IgG antibody and the C3b, C4b, and iC3b components of the . . .
3K - last updated 2006-04-25 20:55 UTC by PeterDAdamo
Optimum Proportions Determination (Flocculation Optima)
[[Serology]] ====See Also==== * [[Flocculation]] * [[Precipitin]] This is a convenient way to estimate . . . antibody concentrations roughly. Unless something is . . . the two most rapid tubes. From the antigen and antibody dilutions present in these tubes, it may be . . . what would be a suitable dilution of antigen and antibody for the "fine test." The serum dilution should . . .
5K - last updated 2006-05-11 10:18 UTC by PeterDAdamo
P (P1, P2) Blood Group
[[Polymorphism]] ====Description==== The biochemical nature of the antigens of the P blood group has . . . to other organisms. The Donath-Landsteiner antibody, found in cases of paroxysmal cold hemoglobinuria, . . . in nature. In adults, the Donath-Landsteiner antibody may appear in transient association with syphilis. . . . carbohydrate structure that stimulates the autoantibody production. Recently, another virus, parvovirus . . .
3K - last updated 2006-06-11 04:11 UTC by DonStJohn
[[Immunology]] ====See Also==== * [[Lectins]] * [[Boyd's Report of Lectin Specificity]] ====Biographic . . . are also antigenic (able to induce antigen antibody reactions). Ehrlich’s work with these lectins . . .
2K - last updated 2006-05-02 18:03 UTC by PeterDAdamo
Specificity of isoagglutinin response following injection of group substances into group O individuals
[[References]] Specificity of isoagglutinin response following injection of group substances into group . . . the A substance or to nonspecific stimulation of antibody which may follow the injection of any antigen. . . .
2K - last updated 2006-05-03 12:38 UTC by PeterDAdamo
The composition of specific precipitates in the region of antigen excess
[[References]] ====THE COMPOSITION OF SPECIFIC PRECIPITATES IN THE REGION OF ANTIGEN EXCESS==== Saul . . . a linear relation is found between the ratio of antibody to antigen in the precipitate and the amount . . .
2K - last updated 2006-05-03 12:27 UTC by PeterDAdamo
Thomsen-Friedenreich (T-Tn) antigen
[[Serology]] ====See Also==== * [[Mucin]] * [[Galectin 3, hGal-3]] * [[Neo-Springerism]] ====Description==== . . . type A individuals have the least aggressive antibody immune response against the T and probably . . . goes that because of the lower level of antibody against T and Tn antigens or stumps, and because . . . controls) have depressed levels of anti-T antibody. * Springer GF, Desai PR, Scanlon EF. Blood . . . if they do, would not likely mount much of an antibody response against them. ====Neo Springerism: . . .
23K - last updated 2006-04-28 21:54 UTC by PeterDAdamo
Von Willebrand factor (vWF)
[[Biochemistry]] ====See Also==== * [[Factor VIII]] * [[Clotting factors]] ====Description==== <b>Von . . . is either deficient or has been inhibited by [[Antibody|antibodies]] directed at the enzyme. This . . .
6K - last updated 2007-05-29 03:53 UTC by AlanGoldenberg
[[Lectinology]] ====See Also==== * [[AB Isogenes]] * [[A.E. Mourant]] * [[Archaeogenetics]] * [[Blood . . . Mourant.]] Later, Boyd discovered [[Lectins]], antibody-like proteins, in plants. In 1945, at the . . . precipitation]] * [[Influence of character of antibody upon velocity of floculation]] * [[Separation . . .
7K - last updated 2006-08-04 07:44 UTC by TomGreenfield
36 pages found.