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19q13.3
[[Polymorphism]] ====See Also==== * [[Locus]] * [[Allele]] * [[H-h blood group system]] ====Description==== . . . having a particular combination of two specific alleles at a given locus can be calculated using a . . .
3K - last updated 2006-05-13 07:08 UTC by AlanGoldenberg
Alexander Wiener
[[Serology]] * [[Fisher-Race Theory of Rhesus Inheritance]] * [[Wiener Theory of Rhesus Inheritance]] . . . occurs one Rh gene, but this gene has multiple alleles. For example, one gene R1 produces one agglutinogen . . .
3K - last updated 2006-05-31 17:48 UTC by PeterDAdamo
Allele
[[Genomics]] ====See Also==== * [[Allele]] * [[Chromosome]] * [[DNA]] * [[Genotype]] * [[Genetic architecture]] . . . locus, or location, on a chromosome. Different alleles produce variation in inherited characteristics . . . or blood type. In an individual, one form of the allele (the [[dominant]] one) may be expressed more . . . than another form (the [[recessive]] one). An allele is any one of a number of viable [[DNA]] codings . . . [[genotype]] for that gene will be the set of alleles it happens to possess. In an organism which . . .
5K - last updated 2006-05-27 14:57 UTC by TomGreenfield
Amorph
[[Genomics]] ====See Also==== * [[Genotype]] * [[Phenotype]] * [[Mutation]] * [[Single nucleotide polymorphisms . . . (SNPs)]] * [[Allele]] ====Description==== An amorphic mutation, . . . at a molecular level, also called a null allele. ====Discussion==== In the human [[ABO Blood . . . Group|ABO blood group]] system, the [[Allele|alleles]] for the A-[[antigen]] and B-antigen . . . if both are present, giving blood type AB. The allele for O blood type, however, is actually exactly . . .
2K - last updated 2006-05-27 12:34 UTC by PeterDAdamo
Antigen, ABH
[[Immunology]] ====See Also==== * [[Blood group antigen proteins (chart)]] * [[Antigen]] * [[ABO Antibodies]] . . . A and B transferases encoded by the functional [[allele|alleles]] (A and B alleles) of a single gene . . . synthesis, while the transferase coded by the O allele is non-functional; therefore, the acceptor substrate, . . . found in a large number (but not all) of O alleles and responsible for the loss of the activity . . . and Hakamori). In addition to four common alleles (A1, A2, B and O), numerous alleles which encode . . .
21K - last updated 2006-06-30 16:34 UTC by PeterDAdamo
Average linkage tree (classical methods)
[[Paleoserology]] ====See Also==== * [[Luigi Cavalli-Sforza]] http://www.dadamo.com/wiki/pcclass.jpg . . . (modifed Nei) calculated on the basis of 120 allele frequencies from the following systems: A1A2B0, . . . TF, GC, LE, LPA, PEPA, PEPB, PEPC, AG, HLAA (12 alleles), HLAB (17 alleles), P1, CP, ACPI, PGD, PGM1, . . .
1K - last updated 2006-05-26 11:35 UTC by PeterDAdamo
Biometrics and biostatistics
[[Anthropometry]] ====See Also==== * [[Auxology]] ====Description==== Biostatistics or biometry is the . . . work can assist in finding candidates for gene alleles that can cause or influence predisposition . . .
2K - last updated 2006-05-06 10:27 UTC by PeterDAdamo
Clines
[[Paleoserology]] ====See Also==== * [[Blood Groups and Anthropology]] * [[Blood Groups, Races and People]] . . . The gradual decrease in frequency of the B blood allele going west in Europe is an example of such a . . .
1K - last updated 2006-05-08 05:59 UTC by TomGreenfield
DNA methyltransferase
[[Genomics]] ====See Also==== * [[Base pair]] * [[CpG sites]] * [[DNA]] * [[Epigenetics]] * [[Histone . . . of genes normally not expressed by the maternal allele. DNMT3L interacts with DNMT3a and DNMT3b and . . .
7K - last updated 2006-08-26 07:11 UTC by AlanGoldenberg
Deoxyribonucleic acid (DNA)
[[Genomics]] ====See Also==== * [[Allele]] * [[Base pair]] * [[Chromosome]] * [[Genetic architecture]] . . .
10K - last updated 2006-07-06 11:22 UTC by PeterDAdamo
Duffy blood group system
[[Polymorphism]] ====See Also==== * [[Allele]] * [[Chemokines]] * [[Interleukin-8 (IL-8)]] FY Gene locus . . . malaria Plasmodium vivax parasite. ====About the alleles==== The [[Antigen|antigenic]] determinants . . . domain. The system is defined by three common [[Allele|alleles]]: FYA and FYB encode two antithetical . . . (ES stands for erythroid silent) is the major allele in African American and Blacks and occurs rarely . . . has been documented for only a few types of rare alleles, FYBWK (WK stands for "weak") and FYAO or FYBO. . . .
15K - last updated 2006-05-14 19:52 UTC by PeterDAdamo
FUT3
[[Nutrigenomics]] ====See Also==== * [[FUT1]] * [[FUT2]] * [[FUT4]] * [[19q13.3]] * [[Lewis antigens]] . . . saliva from homozygotes with 2 functional FUT2 alleles was less strongly recognized than saliva from . . . with 1 functional and 1 inactivated FUT2 allele. Partial fucosidase treatment of duodenal tissue . . .
6K - last updated 2006-05-06 12:06 UTC by PeterDAdamo
Factor VIII
[[Biochemistry]] ====See Also==== * [[Clotting factors]] * [[Rheology]] * [[Von Willebrand factor (vWF)]] . . . in young adults. }}) The ABO “O” and “A” alleles also show a significant association with the . . .
10K - last updated 2006-06-27 10:25 UTC by PeterDAdamo
Fatty acid binding protein 2 (FABP-2) polymorphism, obesity and insulin resistance
[[References]] ====Fatty acid binding protein 2 (FABP-2) polymorphism, obesity and insulin resistance.==== . . . long chain fatty acids. Carriers of the Thr54 allele in FABP2 have a 2-fold greater affinity for . . . supports a role of the polymorphism of this allele in the etiology of metabolic disorders. The . . .
2K - last updated 2006-05-06 11:10 UTC by PeterDAdamo
Gc plasma system
[[Polymorphism]] ====See Also==== ====Description==== The Gc groups of the plasma are the expression . . . is the carrier of vitamin D. There are numerous alleles of which only two, Gcl and Gc2, are relatively . . . on electrophoresis. The distribution of the alleles and the possible relation of this to sunshine . . .
2K - last updated 2006-05-14 20:41 UTC by PeterDAdamo
Genetic polymorphisms in dietary xenobiotic metabolizing enzymes
[[Genomics]] ====See Also==== * [[Cytochrome P450 oxidase]] * [[Xenobiotics]] ====Description==== ||<b>Gene</b>||<b>Polymorphic . . . alleles</b> ||<b>Effect on enzyme function</b>|| . . . *6A, *6B, *7A, 7B, *12A, *13, *13B||Low activity alleles || ||GSTA1||Al*1 ||High transcriptional activity|| . . . ||Low transcriptional activity|| ||GSTM1||Null allele ||No activity|| ||GSTT1||Null allele ||No activity|| . . .
2K - last updated 2006-07-03 12:08 UTC by PeterDAdamo
H-h blood group system
[[Polymorphism]] ====See Also==== * [[Allele]] * [[Antigen]] * [[Blood group antigen proteins (chart)]] . . . reside on [[Mucin|mucins]] in secretions. When [[allele|alleles]] of both genes fail to express active . . . proteins==== Primary gene products of functional alleles are closely homologous alpha 1,2 [[fucosyltransferases]] . . . Blood, 95:3641-3643, 2000}}). ====About the alleles==== A large number of [[Allele|alleles]] of . . . group [[phenotype]] of individuals bearing such alleles will depend on whether FUT1 or FUT2, or both . . .
12K - last updated 2006-08-06 20:50 UTC by TomGreenfield
Haplogroups
[[Archaeogenetics]] ====See Also==== * [[Mitochrondrial DNA Haplogroups]] * [[Y chromosome analysis]] . . . [[Haplotype|haplotypes]], which are series of [[Allele|alleles]] at specific locations on a [[chromosome]]. . . . mixing the rate of genetic drift for common [[alleles]] is very slow; however, in a very small interbreeding . . .
6K - last updated 2006-05-27 12:31 UTC by PeterDAdamo
Hardy-Weinberg Principle
[[Genomics]] ====See Also==== * [[Allele]] * [[Genotype]] * [[Locus]] * [[Phenotype]] ====Description==== . . . can be represented as a simple function of the allele frequencies at that locus. In the simplest case . . . of a single [[locus]] with two [[Allele|alleles]] A and a with allele frequencies of . . . description for the HWP is that the alleles for the next generation for any given individual . . . and independent of each other. Consider two alleles, A and a, with frequencies p and q, respectively, . . .
4K - last updated 2006-06-13 10:10 UTC by PeterDAdamo
Histone
[[Genomics]] ====See Also==== * [[Allele]] * [[Chromatin]] * [[Chromosome]] * [[Deoxyribonucleic acid . . .
8K - last updated 2006-07-07 10:26 UTC by PeterDAdamo
Interleukin-1 (IL-1)
[[Immunology]] ====See Also==== * [[Toll-like receptors (TLRs)]] * [[Interleukin-6 (IL-6)]] * [[Cytokines]] . . . associated with LBM. The carriers of the +3954T allele had a lower prevalence of inflammation (p<0.05) . . .
4K - last updated 2006-05-13 10:00 UTC by PeterDAdamo
Interleukin-4 (IL-4)
[[Immunology]] ====See Also==== * [[Dietary lectins can induce in vitro release of IL-4 and IL-13 from . . . allergic inflammatory disorders. The variant [[allele]] consisted of an A-to-G transition at nucleotide . . . interleukin-4 receptor alpha protein. The R576 allele was found in 3 of 3 patients with the hyper-IgE . . . relative risk of atopy among those with a mutant allele was 9.3. The R576 allele was associated with . . . of CD23 by interleukin-4 than was the wildtype allele. This enhanced signaling was associated with . . .
4K - last updated 2006-05-17 00:54 UTC by AlanGoldenberg
Kell Blood Group
[[Polymorphism]] ====See Also==== * [[Allele]] * [[Antigen]] * [[Blood group systems]] * [[Glycoproteins]] . . . PMID 10438732}}) There are several [[allele]]s of the [[gene]] which creates Kell protein. . . . Two such alleles, ''K<sub>1</sub>'' (Kell) and ''K<sub>2</sub>'' . . . muscle, Kell is disulfide-linked to XK. ====Alleles==== Antigens are carried on a 93 kDa type II . . . chromosome [[locus]] 7 q35-6. ====About the alleles==== KEL: As determined by serological analyses, . . .
17K - last updated 2006-07-21 10:45 UTC by TomGreenfield
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
[[Nutrigenomics]] ====See Also==== ====Description==== * Species: Homo sapiens * Chromosome: 16; Location: . . . and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin . . . expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. . . .
2K - last updated 2006-05-25 10:01 UTC by PeterDAdamo
Mid digital hair
[[Polymorphism]] ====See Also==== * [[Digit ratio]] ====Description==== Danforth ({{Danforth, C. H., . . . They offered the hypothesis of five multiple alleles, D0, D1,D2,D3, D4 (listed in order of increasing . . .
2K - last updated 2006-05-15 14:46 UTC by PeterDAdamo
Natural Killer (NK) Cells
[[Immunology]] ====See Also==== * [[T lymphocyte]] * [[Cell mediated immunity]] * [[Cytokines]] ====Definition==== . . . lack of expression of one or more HLA class I alleles leads to NK-mediated target cell lysis ({{Moretta . . .
8K - last updated 2006-05-03 21:02 UTC by PeterDAdamo
Neutral theory of molecular evolution
[[Genomics]] ====See Also==== * [[ABO and Secretor Blood group Genetics]] * [[Genetic drift]] * [[Motoo . . . is the result of genetic drift acting on neutral alleles. A new allele arises typically through the . . . such an event immediately contributes a new allele to the population, and this allele is subject . . . and offspring does the mutation contribute a new allele to the population. Neutral substitutions create . . . new neutral alleles. Through drift, these new alleles may become . . .
9K - last updated 2006-07-10 14:47 UTC by ool-43560645.dyn.optonline.net
P (P1, P2) Blood Group
[[Polymorphism]] ====Description==== The biochemical nature of the antigens of the P blood group has . . . worm infestation. The distribution of the p2 [[allele]] runs north to south and way from 180 degrees . . . frequencies reported by Blangero for the P2 allele are Circumpolar people, Oriental, and Pacific . . . and aquatic mammal diets. Thus the high P2 allele may result from ensuing [[Helminthiasis]]. ====Abstracts==== . . .
3K - last updated 2006-06-11 04:11 UTC by DonStJohn
Paraoxonase 2 (PON2) polymorphism
[[Polymorphism]] ====See Also==== * [[Fatty acid binding protein 2 (FABP-2) polymorphism]] ====Description==== . . . data indicating that the PON1*B and PON2*S [[allele]]s contribute synergistically to the CHD risk . . .
3K - last updated 2006-05-21 06:41 UTC by AlanGoldenberg
Phenotype
[[Genomics]] ====Description==== The phenotype of an individual organism is either its total physical . . . by [[genotype]], or by the identity of the alleles that an individual carries at one or more positions . . . Thus, the identity of one or a few known alleles does not always enable prediction of the phenotype. . . .
2K - last updated 2006-05-27 12:26 UTC by PeterDAdamo
Ploidy
[[Genomics]] ====See Also==== * [[Allele]] * [[Centromere]] * [[Chromosome]] * [[Differentiation, cellular]] . . .
7K - last updated 2006-06-26 10:09 UTC by PeterDAdamo
Quantitative trait locus analysis
[[Genomics]] ====See Also==== * [[Epistasis]] * [[Genetic linkage]] * [[Haplotype]] * [[Phenotype]] ====Description==== . . . chromosomes and each gene may have two or more alleles.Once a region of DNA is identified as contributing . . . QTL mapping is the statistical study of the alleles which occur in a locus and the phenotypes (physical . . .
6K - last updated 2006-06-27 10:51 UTC by PeterDAdamo
RNA (ribonucleic acid)
[[Genomics]] ====See Also==== * [[Allele]] * [[Chromosome]] * [[Deoxyribonucleic acid (DNA)]] * [[Genetic . . .
6K - last updated 2006-07-06 11:10 UTC by PeterDAdamo
The malate dehydrogenase system
[[Polymorphism]] ====See Also==== ====Description==== The red cell enzyme malate dehydrogenase is an . . . reaction). ====Discussion==== Several [[Allele|alleles]] are known but most populations are . . . uniformly homozygous for one allele SMDH1. Most other alleles are very rare but . . .
2K - last updated 2006-06-05 07:40 UTC by AlanGoldenberg
Thymidylate synthase (TS) polymorphism
[[Polymorphism]] ====See Also==== * [[Methylenetetrahydrofolate reductase (MTHFR) polymorphism]] * [[5,10-methylenetetrahydrofolate . . . has been reported among Japanese individuals ([[allele]] frequency 19%), but has not been investigated . . . and used the combined genotype with zero variant allele (TSER 2R and TS3'UTR 6 bp variant alleles) as . . . the combined genotype with three or four variant alleles was associated with a significantly increased . . . gastric cancer, and the TSER 2R and TS3'UTR 6 bp alleles may jointly play a role in the etiology of . . .
6K - last updated 2006-05-26 07:16 UTC by AlanGoldenberg
Wiener Theory of Rhesus Inheritance
[[Genomics]] ====See Also==== * [[Fisher-Race Theory of Rhesus Inheritance]] * [[Rhesus (Rh) Blood Group]] . . . occurs one Rh gene, but this gene has multiple alleles. For example, one gene R1 produces one [[Agglutinin|agglutinogen]] . . . e respectively in the Fisher-Race nomenclature. Alleles of the one gene could be R2 (cDE in Fisher-Race), . . . has only one gene locus at which multiple [[allele]]s occur. ====Links==== . . .
2K - last updated 2006-09-07 18:37 UTC by TomGreenfield
William Boyd
[[Lectinology]] ====See Also==== * [[AB Isogenes]] * [[A.E. Mourant]] * [[Archaeogenetics]] * [[Blood . . . are populations that differ according to their [[Allele|alleles]]. On this basis, he divided the world . . .
7K - last updated 2006-08-04 07:44 UTC by TomGreenfield
37 pages found.