Tumor Necrosis Factor (TNF)

Immunology?

See Also

• [Tumor Necrosis Factor alpha (TNFa)]?

Description

Tumor Necrosis Factor (TNF) comes in two variants: alpha and beta.

• [Tumor Necrosis Factor alpha (TNFa)? TNF-alpha] is a major immune response-- modifying cytokine produced primarily by activated macrophages. TNF-alpha increases cellular responsiveness to growth factors and induces signaling pathways that lead to proliferation.
• TNF-beta, produced by cytotoxic T-cells, is characterized by its ability to kill a number of different cell types and induce other to differentiate into other forms which result in their death.

Discussion

One of the main immune system [Growth Factors]?.

TNF-alpha is a critical part of the rejection process that occurs when someone is transfused with the wrong blood type.

• Davenport RD, Strieter RM, Kunkel SL Red cell ABO incompatibility and production of tumour necrosis factor-alpha. Br J Haematol 1991 Aug;78(4):540-4

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