C O N T E N T SSee AlsoDescriptionThere is a possible association between the Trp64Arg polymorphism and insulin resistance (IR). Numerous studies have been conducted to examine the relationship between the ß3-adrenergic receptor Trp64Arg polymorphism and components of IR syndrome. However, the results have been inconsistent and have led to controversy about whether this polymorphism is associated with these clinical features. A recent meta-analysis demonstrated the moderate effects of the Trp64Arg polymorphism on IR in the Asian population and in obese and diabetic subgroups. (1) AbstractsEnergy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor geneDiabetes Obes Metab. 2006 May;8(3):322-30. Hojlund K, Christiansen C, Bjornsbo KS, Poulsen P, Bathum L, Henriksen JE, Lammert O, Beck-Nielsen H.
LinksReferences1. Siyan Zhan and Suzanne C. Ho Meta-Analysis of the Association of the Trp64Arg Polymorphism in the ß3 Adrenergic Receptor with Insulin Resistance Obesity Research 13:1709-1719 (2005) |
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