Histone methyltransferases (HMT)

Genomics

See Also

• DNA?
• Base pair
• [CpG sites]?
• Epigenetics?
• Histone
• [Histone methyltransferases (HMT)]?
• Maternal effect
• Methylation?
• Methylenetetrahydrofolate reductase (MTHFR) polymorphism
• Nucleotide
• Phenotypic plasticity
• [5,10-methylenetetrahydrofolate reductase (MTHFR)]?

Description

Histone methyltransferases (HMT) are enzymes, histone-lysine N-methyltransferase and histone-arginine N-methyltransferase, which catalyze the transfer of one to three methyl groups from the cofactor s-adenosylmethionine to lysine and arginine residues of histone proteins. These proteins often contain an SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain, however the recently discovered HMT Dot1 lacks the characteristic SET domain.

Discussion

Histone methylation serves in epigenetic gene regulation. Methylated histones bind DNA more tightly, which inhibits transcription.

Links

Attribution

• This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Histone methyltransferase.