Difference (from prior minor revision) Changed: 18c18 < * Pseudomonas aeruginosa is the most frequent bacterial pathogen causing acute diffuse otitis externa. In this investigation, human ABO blood group antigens were analysed on outer ear canal epithelial cells with standard routine histological procedures by monoclonal antibodies for the blood groups A and B, and with Ulex europaeus I lectin for the blood group O, respectively. In all cases (n = 20) the blood groups could be shown immunohistologically. P. aeruginosa-specific adhesion and inhibition assays were performed in the presence of [[N-acetylgalactosamine]] (GalNAc), [[N-acetylglucosamine]] (GlcNAc), [[D-mannose]] and A-like substance. Amongst others, P. aeruginosa present adhesion molecules (lectins) with specificity for GalNAc. Thus, the correlation between blood group A phenotype and P. aeruginosa-induced acute diffuse otitis externa was investigated. Statistical evaluation proved a highly significant association. These data support the hypothesis that P. aeruginosa lectins with GalNAc specificity apparently adhere to GalNAc moieties, representing the terminal blood group A-determinant and further indicate that patients presenting with blood group A may have a genetic disposition for this form of otitis externa. to > * Pseudomonas aeruginosa is the most frequent bacterial pathogen causing acute diffuse otitis externa. In this investigation, human ABO blood group antigens were analysed on outer ear canal epithelial cells with standard routine histological procedures by monoclonal antibodies for the blood groups A and B, and with Ulex europaeus I lectin for the blood group O, respectively. In all cases (n = 20) the blood groups could be shown immunohistologically. P. aeruginosa-specific adhesion and inhibition assays were performed in the presence of [[N-acetylgalactosamine]] (GalNAc), [[N-acetylglucosamine]] (GlcNAc), [[D-mannose]] and A-like substance. Amongst others, P. aeruginosa present adhesion molecules ([[lectins]]) with specificity for GalNAc. Thus, the correlation between blood group A phenotype and P. aeruginosa-induced acute diffuse otitis externa was investigated. Statistical evaluation proved a highly significant association. These data support the hypothesis that P. aeruginosa lectins with GalNAc specificity apparently adhere to GalNAc moieties, representing the terminal blood group A-determinant and further indicate that patients presenting with blood group A may have a genetic disposition for this form of otitis externa. C O N T E N T SSee AlsoMaternal blood group in otitis media with effusionClin Otolaryngol 1994 Aug;19(4):327-331 Gannon MM, Jagger C, Haggard MP Department of Epidemiology and Public Health, University of Leicester, UK.
Distribution of ABO blood groups in secretory otitis media and cholesteatoma.Clin Otolaryngol 1983 Aug;8(4):263-265 Mortensen EH, Lildholdt T, Gammelgard NP, Christensen PH
Blood group phenotype determines lectin-mediated adhesion of Pseudomonas aeruginosa to human outer ear canal epitheliumInt J Med Microbiol Virol Parasitol Infect Dis 1995 Apr;282(3):287-295 Steuer MK, Beuth J, Hofstadter F, Probster L, Ko HL, Pulverer G, Strutz J Department of Otorhinolaryngology, University of Regensburg.
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