LECSTER LECTIN DATABASE
LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.
Programmed and curated by Peter D'Adamo.
The Lecster database is
searchable by several fields. They are identified and explained here.
This is the standard scientific nomenclature,
considered archaic, trivial names and three letter abbreviations
constitute the most common way many lectin are represented in the literature.
is most usually whatever common name the source of the lectin or galectin is
known by, if any.
is most usually where the lectin has been isolated. They are identified in table
overall specificity of the lectin or galectin. When the specificity has been
determined in detail, the most inhibitory compound is indicated in brackets.
glycoconjugates have been shown to inhibit biological activity (most usually
biologic systems have been shown to be influenced by the lectin, with relevant
literature references. These are most often hemagglutination or mitogenic
reactions. ABO or other blood group specificity provided when possible.
which can be consider authoritative as far as characterization of the lectin is
function reports with relevant literature citations
Lecster uses an expanded lectin nomenclature
system originally proposed for plant lectins by Van Damme et al (Handbook of
Plant Lectins, John Wiley & Sons). This allows
a more specific identification of the lectin and carries with it the added
benefit of much relevant information being contained directly in the key. Also,
once comprehended, it becomes perhaps the most sophisticated way to search
Lecster via partial entries.
takes the following form:
An explanation of each index variable follows.
LLL refers to the general category
of agglutinin. At this point six general categories are recognized: lectins (LEC),
integrins (INT), cadherins (CDH), annexins (ANN), selectins (SEL) and galectins (GLT). The x value refers to the taxonomic groups of the
agglutinin, Table 1 summarizes these categories:
||Lectin or galectin from higher
animal, typically vertebrates.
||Lectin or galectin from
||Lectin or galectin from
||Lectin from fungi
||Lectin from Bacteria
Ggg stands for the three first letters of the plant genus name (in Latin).
Sss stands for the three first letters of the plant species name (in Latin).
ti refers to the tissue from which the lectin has been isolated. Table
summarizes the indices used for the various tissues.
|Serum or plasma
vertebrates, Invertebrates, Bacteria, Unicellular, Virus, Fungal
T refers to the lectin subtype. Hololectins, merolectins, chimerolectins and superlectins are indicated by the letters H, M, C and S, respectively.
sp refers to the specificity group. Each group is indicated by the index given in Table
| Mannose/maltose-binding lectins
| Mannose/glucose-binding lectins
| Fucose-binding lectins
| Sialic acid-binding lectins
| Lectins with a complex but known specificity
| Lectins with a complex and unknown specificity
| Lectins with a dual specificity
| Lectins with an undetermined specificity
N is used to distinguish different lectins of the same specificity group which may occur in the same tissue of a single plant species. When a plant contains only one lectin of a given specificity in a particular tissue, the number is 1. In case different lectins of the same specificity are found in the same tissue, numbers refer to the (chronological) order of their discovery.
is the most specific category the lectin can be classified under.