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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Vicia faba : Fava bean, broad bean
VFA, Favin

Molecular structure of
Fava bean, broad bean:VFA, Favin

Vicia faba

Lecster ID:644 Edit Entry
Source Organism:Fava bean, broad bean
Species:Vicia faba
Common Nomenclature:VFA, Favin
Class:Legume lectin
Index Nomenclature:LECp.Vic.Fab.xx.Xxxx
Characterization Notes:The lectin behaves as a 'cold agglutinin' displaying stronger agglutination than the naturally occurring ABO agglutinin in the cold. For discussion of characteristics of Favin, see: J Biol Chem 1979 Jul 25;254(14):6803-10
Biological Activity:Agglutinates human group A erythrocytes at a titer of 1:4; group B erythrocytes at a titer of 1:1; by crude lectin preparation (16mg/ml). See: Int J Cancer 1970;6:283

Dietary lectins can alter the proliferation of colonic cells.

A normal healthy cell is said to be well differentiated, meaning that its characteristic features and structures are intact. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding.

Researchers from Hammersmith Hospital, London, assessed the effects of dietary lectins on the behavior of cancer cells in the colon.

VFA (broad bean lectin) stimulated an undifferentiated colon cancer cell line to differentiate into gland like structures. The adhesion molecule epCAM is involved in this. See: Gut 1999 May;44(5):709-14
Source Tissue:Seed
Specificity: The purified lectin shows a high affinity for N-acetyl-D-glucosamine (GlcNAc); D-mannose
References:Prep Biochem 1984;14(4):373-87

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By Peter D'Adamo. Copyright 2001-2011.