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Copyright 2001-2011.

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Rana catesbeiana ovum lectin : Frog eggs

Molecular structure of
Frog eggs:cSBL

Rana catesbeiana ovum lectin

Lecster ID:554 Edit Entry
Source Organism:Frog eggs
Species:Rana catesbeiana ovum lectin
Common Nomenclature:cSBL
Class:Lectins Displaying RNase Activity (Leczymes)
Index Nomenclature:LECa.Ran.Cat.xx.Xxxx
Characterization Notes:Lectin isolated from Rana catesbeiana eggs preferentially agglutinates a large variety of human and animal tumor cells but not normal red blood cells, lymphocytes, or fibroblasts. The phenomenon correlates with a higher binding activity of the lectin with tumor cells. The lectin-dependent tumor cell agglutination is due to a high density of sialic acid at the cell surface
Biological Activity:Two sialic acid-binding lectins, isolated from eggs of Rana catesbeiana (cSBL) and R. japonica (jSBL), agglutinate a large variety of tumor cells, but do not agglutinate normal red blood cells and fibroblasts.
Source Tissue:
Inhibitors:This agglutinating activity is inhibited by sialoglycoproteins and gangliosides. Treatment of tumor cells with sialidase greatly reduced the lectin-dependent agglutination, and the sialidase-dependent reduction of tumor cell agglutination was inhibited by
References:Cancer Res 1987 Sep 15;47(18):4877-83 Biochem Biophys Res Commun 1991 Jul 15;178(1):407-13

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2015-1-25: Current Date 10:33:21 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.