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Rana catesbeiana ovum lectin : Frog eggs
cSBL
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Molecular structure of
Frog eggs:cSBL
|
Rana catesbeiana ovum lectin
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| Lecster ID:554 | Edit Entry |
| Source Organism: | Frog eggs |
| Species: | Rana catesbeiana ovum lectin |
| Common Nomenclature: | cSBL |
| Class: | Lectins Displaying RNase Activity (Leczymes) |
| Index Nomenclature: | LECa.Ran.Cat.xx.Xxxx |
| Characterization Notes: | Lectin isolated from Rana catesbeiana eggs preferentially agglutinates a large variety of human and animal tumor cells but not normal red blood cells, lymphocytes, or fibroblasts. The phenomenon correlates with a higher binding activity of the lectin with tumor cells. The lectin-dependent tumor cell agglutination is due to a high density of sialic acid at the cell surface |
| Biological Activity: | Two sialic acid-binding lectins, isolated from eggs of Rana catesbeiana (cSBL) and R. japonica (jSBL), agglutinate a large variety of tumor cells, but do not agglutinate normal red blood cells and fibroblasts. |
| Source Tissue: | |
| Specificity: | |
| Inhibitors: | This agglutinating activity is inhibited by sialoglycoproteins and gangliosides. Treatment of tumor cells with sialidase greatly reduced the lectin-dependent agglutination, and the sialidase-dependent reduction of tumor cell agglutination was inhibited by |
| References: | Cancer Res 1987 Sep 15;47(18):4877-83 Biochem Biophys Res Commun 1991 Jul 15;178(1):407-13 |
2013-6-19: Current Date 6:36:38 GMT: Current Time
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