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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Phytolacca americana : Poke weed
PWM, Pa-1, Pa-2 (PL-A) Pa-3, Pa-4 (PL-C), Pa-5

Molecular structure of
Poke weed:PWM, Pa-1, Pa-2 (PL-A) Pa-3, Pa-4 (PL-C), Pa-5

Phytolacca americana

Lecster ID:530 Edit Entry
Source Organism:Poke weed
Species:Phytolacca americana
Common Nomenclature:PWM, Pa-1, Pa-2 (PL-A) Pa-3, Pa-4 (PL-C), Pa-5
Characterization Notes:Five mitogens, designated Pa-1 through Pa-5

Among these mitogens, only Pa-1 was mitogenic for both murine B-cells and T-cells, and the other mitogens were T-cell mitogens. Pa-2, the strongest T-cell mitogen.

Three mitogenic lectins, designated PL-A, PL-B, and PL-C, were purified from the roots of pokeweed (Phytolacca americana).Although all of three lectins have mitogenic activities, PL-B is a mitogenic lectin with the most potent hemagglutinating and mitogenic activities, and PL-C has almost no hemagglutinating activity.

Biological Activity:Human B lymphocytes activated by pokeweed mitogen (PWM) undergo a proliferative response, differentiate into immunoglobulin producing cells (IPC), and release immunoglobulin into the supernatant fluid of the lymphocyte cultures. See: Ann Clin Lab Sci 1982 Nov-Dec;12(6):455-62 for further characterization, see: Biochemistry. 1974 Aug 27;13(18):3671-7

Pokeweed Antiviral Protein a novel cap-binding protein, PAP is a type I ribosome-inactivating protein (RIP) isolated from Phytolacca americana.

Several cap-binding proteins mediate processes such as pre-mRNA splicing, translation initiation, and mRNA turnover. PAP also cleaves supercoiled DNA into relaxed and linear forms.

B-cell precursor (BCP) leukemia represents one of the most radiation-resistant forms of human malignancy. PAP caused apoptosis of radiation-resistant primary BCP leukemia cells and killed greater than 99
Source Tissue:
References:Biosci Biotechnol Biochem 1995 Apr;59(4):683-8

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2015-3-6: Current Date 14:25:49 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.