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|Momordica charantia : Chinese bitter melon|
Molecular structure of
Chinese bitter melon:MCL
|Lecster ID:445|| Edit Entry |
|Source Organism:||Chinese bitter melon|
| Common Nomenclature:||MCL|
|Characterization Notes:||MCL demonstrated antilipolytic and lipogenic activities in isolated rat adipocytes although it did not possess intrinsic lipolytic activity. The antilipolytic activity was susceptible to destruction by heat, trypsin, chymotrypsin, glutathione and galactose, indicating that the integrity of the protein moiety, the disulfide linkages, and galactose, which is the sugar specifically bound by the lectin, all play an important role in interaction with the adipocyte leading to an expression of this insulin-like activity. Trichosanthin is a ribosome inactiviating protein, like ricin.|
|Biological Activity:||agglutinates group A erythrocytes at a titer of 1:256; group B erythrocytes at a titer of 1:512; group B erythrocytes at a titer of 1:512; by crude lectin preparation (16mg/ml). See: Int J Cancer 1970;6:283 2 different lectins have been purified from the seeds of Momordica charantia by gel-filtration and ion-exchange chromatography. These 2 lectins appear to be composed of 2 subunits of 26,000 daltons. Protein fraction I, but not II, showed agglutinating activity toward human type-O red blood cells. See: Experientia 1980 May 15;36(5):524-7|
|References:||Int J Pept Protein Res 1986 Aug;28(2):163-72 Biochem Biophys Res Commun. 1998 Dec 9;253(1):143-6.|
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