LECSTER LECTIN DATABASE










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Copyright 2001-2011.



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Total number of records: 619 Matching records: 1

Maackia amurensis :
MALb, MAHb, MAL, MAHs



Molecular structure of
:MALb, MAHb, MAL, MAHs

Maackia amurensis



Lecster ID:420 Edit Entry
Source Organism:
Species:Maackia amurensis
Common Nomenclature:MALb, MAHb, MAL, MAHs
Class:Legume lectins
Index Nomenclature:LECp.Maa.Amu.se.Hsi1 (MAHs, MAH) LECp.Maa.Amu.se.Hsi2 (MAHs, MAH) LECp.Maa.Amu.ba.Hsi1 (MAHb) LECp.Maa.Amu.ba.Hsi1 (MALb)
Characterization Notes:There are sialic acid-specific leukoagglutinating lectin from the seeds of Maackia amurensis. Maackia has a strong hemagglutininating lectin, called MAH (M. amurensis hemagglutinin) and a potent mitogenic lectin, called MAL (M. amurensis leucoagglutinin).
Biological Activity:Both MAH and MAL agglutinate human erythrocytes in a blood group independent manner. See: J Biol Chem 1974 (249); 2786-2792 MAH is a more potent agglutinin than MAL. Both lectins are mitogenic toward human periferal lymphocytes, but MAL is fivefold more active than MAH. See: J Biol Chem 1974 (249); 2786-2792 MAL stongly agglutinates the murine lymphoma cell line BW5147. See: J Biol Chem 1988 (261);4576-4585 Maackia lectin discriminates between normal and chronic leukemic human erythrocytes. It bind to normal, but not malignat cells. See: Biochem Biophys Res Comm 1995 (209); 921-929
Source Tissue:Bark and seeds
Specificity:MAHs: NANA (Ser/Thr-linked tetrasaccharide) MALs: Results indicate that MAL reacts with greatest affinity with the trisaccharide sequence Neu5Ac/Gc alpha 2,3Gal beta 1,4GlcNAc/Glc.
MAHb: NANA
MALb: NANA
Inhibitors:
References:Glycoconj J 1997 Jun;14(4):449-56 J Biol Chem 1991 Jan 5;266(1):83-8





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2014-9-19: Current Date 1:50:53 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.