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Endothelial Cell-Selective Adhesion Molecule (ESAM)
Molecular structure of
:Endothelial Cell-Selective Adhesion Molecule (ESAM)
|Lecster ID:364|| Edit Entry |
| Common Nomenclature:||Endothelial Cell-Selective Adhesion Molecule (ESAM)|
|Characterization Notes:||ESAM is a new member of the immunoglobulin superfamily. ESAM is selectively expressed in cultured human and murine vascular endothelial cells and revealed high level expression in lung and heart and low level expression in kidney and skin. In situ hybridization analysis indicated that ESAM is primarily expressed in the developing vasculature of the embryo in an endothelial cell-restricted pattern. Epitope-tagged ESAM was shown to co-localize with cadherins and catenins in cell-cell junctions.|
|Biological Activity:||The endothelial cell-selective expression of this immunoglobulin-like adhesion molecule coupled with its in vitro functional profile strongly suggests a role in cell-cell interactions that is critical for vascular development or function.|
|References:||J Biol Chem 2001 May 11;276(19):16223-31|
2013-5-19: Current Date 7:12:32 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.