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Annexin VII, Synexin
Molecular structure of
:Annexin VII, Synexin
|Lecster ID:356|| Edit Entry |
| Common Nomenclature:||Annexin VII, Synexin|
|Biological Activity:||An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. This indicates a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells. See: Neuroreport 2001 May 8;12(6):1139-44 Synexin (annexin VII), a Ca(2+)-dependent phospholipid binding protein, may have a role in surfactant secretion, since it promotes membrane fusion between isolated lamellar bodies (the surfactant-containing organelles) and plasma membranes. Am J Physiol Lung Cell Mol Physiol 2001 May;280(5):L991-8 The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). See: Proc Natl Acad Sci U S A 2001 Apr 10;98(8):4575-80|
|References:||Bioessays. 2001 Feb;23(2):170-8. Review.|
2014-8-30: Current Date 2:43:39 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.