LECSTER LECTIN DATABASE










LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.


Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.



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Total number of records: 619 Matching records: 1

Homo sapiens :
Neurocan



Molecular structure of
:Neurocan

Homo sapiens



Lecster ID:350 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Neurocan
Class:Soluble C-lectin ('Lecticans')
Index Nomenclature:LECh.Xxx.Xxx.xx.Xxxx
Characterization Notes:A proteoglycan core peptide. Neurocan is a member of the chondroitin sulphate (CS) proteoglycan family, which also includes versican/PG-M, agrecan and brevican. Neurocan is a heparin binding proteoglycan. See:Biochem Biophys Res Commun 2000 Jun 7;272(2):449-55 These proteoglycans are characterized by the presence of a hyaluronan-binding domain and a C-type lectin domain in their core proteins. Through these domains, lecticans interact with carbohydrate and protein ligands in the extracellular matrix and act as linkers of these extracellular matrix molecules. See: Cell Mol Life Sci 2000 Feb;57(2):276-89 A proteoglycan core peptide.
Biological Activity:Aggrecan, versican, neurocan, and brevican are important components of the extracellular matrix in various tissues. Their amino-terminal globular domains bind to hyaluronan, but the function of their carboxyl-terminal globular domains has long remained elusive.aggrecan, versican, and brevican lectin domains bind fibulin-2, whereas neurocan does not. As expected for a C-type lectin, the interactions are calcium-dependent, with K(D) values in the nanomolar range as measured by surface plasmon resonance.
Source Tissue:
Specificity:
Inhibitors:
References:J Biol Chem 2001 Jan 12;276(2):1253-61





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2014-9-2: Current Date 12:43:10 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.