LECSTER LECTIN DATABASE










LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.


Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.



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Total number of records: 619 Matching records: 1

Homo sapiens :
P-Selectin



Molecular structure of
:P-Selectin

Homo sapiens



Lecster ID:343 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:P-Selectin
Class:Selectin
Index Nomenclature:SELh.Xxx.Xxx.xx.Xxxx
Characterization Notes:P-selectin and E-selectin expression were markedly up-regulated in colitic rats. P-selectin plays a key role on leukocyte rolling and its blockade attenuates leukocyte adhesion in TNBS-induced colitis. See: Gastroenterology 2001 Apr;120(5):1162-72 P-selectin is up-regulated following irradiation and is a key molecular determinant of leukocyte rolling but not leukocyte adhesion in this inflammatory condition. See:Int J Cancer 2001 Apr 20;96(2):99-109
Biological Activity:
Source Tissue:
Specificity:
Inhibitors:Human P-selectin, ICAM-1 and VAP-1 appear to be the most promising targets when antiadhesive interventions preventing leukocyte-mediated tissue destruction after myocardial ischemia. See: J Am Coll Cardiol 2000 Jul;36(1):122-9
References:





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2014-9-1: Current Date 14:3:57 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.