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|Homo sapiens : |
Molecular structure of
|Lecster ID:343|| Edit Entry |
| Common Nomenclature:||P-Selectin|
|Characterization Notes:||P-selectin and E-selectin expression were markedly up-regulated in colitic rats. P-selectin plays a key role on leukocyte rolling and its blockade attenuates leukocyte adhesion in TNBS-induced colitis. See: Gastroenterology 2001 Apr;120(5):1162-72 P-selectin is up-regulated following irradiation and is a key molecular determinant of leukocyte rolling but not leukocyte adhesion in this inflammatory condition. See:Int J Cancer 2001 Apr 20;96(2):99-109|
|Inhibitors:||Human P-selectin, ICAM-1 and VAP-1 appear to be the most promising targets when antiadhesive interventions preventing leukocyte-mediated tissue destruction after myocardial ischemia. See: J Am Coll Cardiol 2000 Jul;36(1):122-9|
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By Peter D'Adamo. Copyright 2001-2011.