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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Vascular Adhesion Molecule (VCAM-1

Molecular structure of
:Vascular Adhesion Molecule (VCAM-1

Homo sapiens

Lecster ID:342 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Vascular Adhesion Molecule (VCAM-1
Index Nomenclature:LECh.Xxx.Xxx.xx.Xxxx
Characterization Notes:VCAM-1 plays a central role in leukocyte recruitment in colitis and blockade of this adhesion molecule has higher therapeutic effect than immunoneutralization of ICAM-1 or MAdCAM-1 in this experimental model. Lab Invest 2000 Oct;80(10):1541-51 There was enhanced expression of E-selectin, CLA, LFA-1, ICAM-1, VLA-4, VCAM-1, and alphaEbeta7 in psoriatic lesions versus nonlesional skin. See: Lab Invest 2001 Mar;81(3):335-47
Biological Activity:
Source Tissue:
Inhibitors:VCAM-1 is significantly more efficient than MAdCAM-1 in supporting eosinophil rolling under conditions of flow. See: Blood 2000;95:592-601) Chronic administration of anti-VCAM-1 antibody, but not anti-ICAM-1 or anti-MAdCAM-1, resulted in significant atte

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2015-3-6: Current Date 11:21:55 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.