View LECster FAQ |
List Everything!
Total number of records: 619 Matching records: 1
Homo sapiens :
Vascular Adhesion Molecule (VCAM-1
|
Molecular structure of
:Vascular Adhesion Molecule (VCAM-1
| 
Homo sapiens
|
| Lecster ID:342 | Edit Entry |
| Source Organism: | |
| Species: | Homo sapiens |
| Common Nomenclature: | Vascular Adhesion Molecule (VCAM-1 |
| Class: | |
| Index Nomenclature: | LECh.Xxx.Xxx.xx.Xxxx |
| Characterization Notes: | VCAM-1 plays a central role in leukocyte recruitment in colitis and blockade of this adhesion molecule has higher therapeutic effect than immunoneutralization of ICAM-1 or MAdCAM-1 in this experimental model. Lab Invest 2000 Oct;80(10):1541-51 There was enhanced expression of E-selectin, CLA, LFA-1, ICAM-1, VLA-4, VCAM-1, and alphaEbeta7 in psoriatic lesions versus nonlesional skin. See: Lab Invest 2001 Mar;81(3):335-47 |
| Biological Activity: | |
| Source Tissue: | |
| Specificity: | |
| Inhibitors: | VCAM-1 is significantly more efficient than MAdCAM-1 in supporting eosinophil rolling under conditions of flow. See: Blood 2000;95:592-601) Chronic administration of anti-VCAM-1 antibody, but not anti-ICAM-1 or anti-MAdCAM-1, resulted in significant atte |
| References: | |
2013-6-19: Current Date 14:47:13 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.
