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Mucosal addressin cell adhesion molecule-1 (MADCAM-1)
Molecular structure of
:Mucosal addressin cell adhesion molecule-1 (MADCAM-1)
|Lecster ID:341|| Edit Entry |
| Common Nomenclature:||Mucosal addressin cell adhesion molecule-1 (MADCAM-1)|
|Characterization Notes:||Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that mediates recruitment of lymphocytes into the gut mucosa. One study in mice demonstrated that anti-MAdCAM-1 antibody significantly ameliorates DSS-induced colitis, suggesting that MAdCAM-1 may be useful for control of inflammatory bowel diseases. See: J Pharmacol Exp Ther 2000 Oct;295(1):183-9 MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium. MAdCAM-1 on hepatic vessels supported adhesion of alpha4beta7+ lymphocytes (i.e., gut-derived T cells) from patients with inflammatory bowel disease and primary sclerosing cholangitis, providing a mechanism to explain the hepatic recruitment of mucosal lymphocytes in inflammatory liver disease complicating inflammatory bowel disease. See: Hepatology 2001 May;33(5):1065-72|
|Inhibitors:||Several phenylalanine based inhibitors were synthesized as antagonists of the leukocyte cell adhesion process that is mediated through the interactions of the mucosal addressin cell adhesion molecule (MAdCAM) and the integrin alpha4beta7. Analogues 20, 2|
2014-12-20: Current Date 8:12:30 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.