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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Mucosal addressin cell adhesion molecule-1 (MADCAM-1)

Molecular structure of
:Mucosal addressin cell adhesion molecule-1 (MADCAM-1)

Homo sapiens

Lecster ID:341 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Mucosal addressin cell adhesion molecule-1 (MADCAM-1)
Index Nomenclature:LECh.Xxx.Xxx.xx.Xxxx
Characterization Notes:Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that mediates recruitment of lymphocytes into the gut mucosa. One study in mice demonstrated that anti-MAdCAM-1 antibody significantly ameliorates DSS-induced colitis, suggesting that MAdCAM-1 may be useful for control of inflammatory bowel diseases. See: J Pharmacol Exp Ther 2000 Oct;295(1):183-9 MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium. MAdCAM-1 on hepatic vessels supported adhesion of alpha4beta7+ lymphocytes (i.e., gut-derived T cells) from patients with inflammatory bowel disease and primary sclerosing cholangitis, providing a mechanism to explain the hepatic recruitment of mucosal lymphocytes in inflammatory liver disease complicating inflammatory bowel disease. See: Hepatology 2001 May;33(5):1065-72
Biological Activity:
Source Tissue:
Inhibitors:Several phenylalanine based inhibitors were synthesized as antagonists of the leukocyte cell adhesion process that is mediated through the interactions of the mucosal addressin cell adhesion molecule (MAdCAM) and the integrin alpha4beta7. Analogues 20, 2

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2015-3-6: Current Date 16:23:46 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.