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Homo sapiens :
Alpha-6 / Beta-7 integrin
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Molecular structure of
:Alpha-6 / Beta-7 integrin
| 
Homo sapiens
|
| Lecster ID:337 | Edit Entry |
| Source Organism: | |
| Species: | Homo sapiens |
| Common Nomenclature: | Alpha-6 / Beta-7 integrin |
| Class: | Integrin A (or I) domain |
| Index Nomenclature: | INTh.Hom.Sap.xx.Xxxx |
| Characterization Notes: | The alpha4/beta7 integrin is a receptor for MadCAM, fibronectin and VCAM-1. This integrin is only found leukocytes which are directed to the Peyer's Patches of the gut. MadCAM which is an addressin, is only found on Peyer's Patch Endothelium. The alpha4/beta7 integrin is also known as (LPAM-1). Data show that protein synthesis-dependent upregulation of the functional beta7 integrin occurs under conditions when beta4 and beta1 integrins are fully expressed, indicating a sequential appearance of specific adhesion molecules on differentiating eosinophil progenitors. See: Allergy 2000 Sep;55(9):865-72 |
| Biological Activity: | |
| Source Tissue: | |
| Specificity: | |
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2013-5-24: Current Date 1:23:53 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.
