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Alpha-6 / Beta-7 integrin
Molecular structure of
:Alpha-6 / Beta-7 integrin
|Lecster ID:337|| Edit Entry |
| Common Nomenclature:||Alpha-6 / Beta-7 integrin|
|Class:||Integrin A (or I) domain|
|Characterization Notes:||The alpha4/beta7 integrin is a receptor for MadCAM, fibronectin and VCAM-1. This integrin is only found leukocytes which are directed to the Peyer's Patches of the gut. MadCAM which is an addressin, is only found on Peyer's Patch Endothelium. The alpha4/beta7 integrin is also known as (LPAM-1). Data show that protein synthesis-dependent upregulation of the functional beta7 integrin occurs under conditions when beta4 and beta1 integrins are fully expressed, indicating a sequential appearance of specific adhesion molecules on differentiating eosinophil progenitors. See: Allergy 2000 Sep;55(9):865-72|
2014-11-26: Current Date 20:22:18 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.