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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Alpha-7 / Beta-1 integrin

Molecular structure of
:Alpha-7 / Beta-1 integrin

Homo sapiens

Lecster ID:326 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Alpha-7 / Beta-1 integrin
Class:Integrin A (or I) domain
Index Nomenclature:INTh.Hom.Sap.xx.Xxxx
Characterization Notes:The alpha7/beta1 integrin is expressed on skeletal and cardiac muscle at specific stages during muscle development. It is a receptor for laminin-1 and binds to it's E8 domain. This integrin is also found localized in focal contacts when melanoma cells attach to laminin-1, while normal melanocytes do not express this integrin. Since alpha7/beta1 is developmentally regulated in muscle cells, it is thought that this integrin has a role in their development. The expression of the three known splice variants is in addition developmentally regulated. Expression of alpha7B precedes the xpression of alpha7A and alpha7C. Alpha7/beta1 is also a trophoblast specific laminin receptor on which it may serve a specific function during the early postimplantation period. This integrin is also known as VLA-7 (very late activation antigen 7).
Biological Activity:
Source Tissue:

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2015-3-2: Current Date 23:25:34 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.