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Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Alpha-6 / Beta-1 integrin

Molecular structure of
:Alpha-6 / Beta-1 integrin

Homo sapiens

Lecster ID:325 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Alpha-6 / Beta-1 integrin
Class:Integrin A (or I) domain
Index Nomenclature:INTh.Hom.Sap.xx.Xxxx
Characterization Notes:The alpha6/beta1 integrin is expressed on platelets, lymphocytes, monocytes, thymocytes and epithelial cells, on which it functions as a laminin receptor for laminin-1, laminin-2 and laminin-4 in vivo. It is also a receptor for laminin-5, but not in vivo. For laminin-1, the binding site has been localized in the E8 domain of this extracellular matrix molecule. This receptor is also known as VLA-6 (very late activation antigen 6) and GPIc-IIa (glycoprotein Ic-IIa on platelets). The alpha4beta1, alpha4beta7, and alphaEbeta7 integrins may all play a contributory role in the progression of chronic forms of demyelinating disease, and together with their ligands could represent potential targets for improved treatment of some forms of multiple sclerosis. See: J Neuroimmunol 2000 Mar 1;103(2):146-52
Biological Activity:
Source Tissue:

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2015-2-27: Current Date 6:21:47 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.