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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Alpha-4 / Beta-1 integrin

Molecular structure of
:Alpha-4 / Beta-1 integrin

Homo sapiens

Lecster ID:323 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Alpha-4 / Beta-1 integrin
Class:Integrin A (or I) domain
Index Nomenclature:INTh.Xxx.Xxx.xx.Xxxx
Characterization Notes:Alpha4/beta1 is a receptor for fibronectin containing the CS-1 region, which is situated within the IIICS region, and VCAM-1 (vascular cellular adhesion molecule 1). It is present on lymphocytes, monocytes, eosinophils, NK-cells and thymocytes. This integrin plays a role in the invasion of inflammated tissues, and has also been implicated in skeletal myogenesis, neural crest migration and proliferation, lymphocyte maturation and morphogenisis of the placenta and heart. VCAM-1 is an adhesion molecule which is present on cytokine-activated endothelial cells, while fibronectin is part of the extracellular matrix. Alpha4/beta1 is thus involved in both cell-cell and cell-extracellular matrix adhesion. This integrin is also known as VLA-4 (very late activation antigen 4) and LPAM-2 (lymphocyte Peyer's patch HEV adhesion molecule 2 (mouse)).
Biological Activity:
Source Tissue:

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2015-3-5: Current Date 6:44:23 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.