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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :
Alpha-2 / Beta-1 integrin

Molecular structure of
:Alpha-2 / Beta-1 integrin

Homo sapiens

Lecster ID:321 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Alpha-2 / Beta-1 integrin
Class:Integrin A (or I) domain
Index Nomenclature:INTh.Hom.Sap.xx.Xxxx
Characterization Notes:Alpha2/beta1 is a receptor for collagen-I to VI, laminin and possibly fibronectin. It is expressed on B and T lymphocytes, platelets, fibroblasts, endothelial cells and melanoma cells. This receptor is also known as VLA-2 (very late activation antigen 2), GPIa-IIa (glycoprotein Ia-IIa on platelets) and ECMRII (extracellular matrix receptor II) See: Integrin a2b1 is a cell surface adhesion receptor for collagen and the human pathogen echovirus-1. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression. See: J Biol Chem. 1995 Jun 2;270(22):13548-52
Biological Activity:
Source Tissue:
References:J Biol Chem 272 pp. 28512 (1997)

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2015-3-1: Current Date 19:32:22 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.