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|Homo sapiens : |
Molecular structure of
|Lecster ID:318|| Edit Entry |
| Common Nomenclature:||Galectin VIII|
|Class:||Tandem Repeat S-lectin or galectin|
|Index Nomenclature:||GLTh.Hom .Sap.xx.Xxxx|
|Characterization Notes:||galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. It inhibits adhesion of human carcinoma (1299) cells to plates coated with integrin ligands, and induces cell apoptosis. galectin-8 also interacts with other members of the integrin family, like (alpha)(6)(beta)(1 )integrins. In contrast, galectin-8 only minimally interacts with (alpha)(4 )or (beta)(3 )integrins. We propose that galectin-8 is an integrin binding-protein that interacts to a different extent with several, but not all members of the integrin family. Binding of galectin-8 modulates integrin interactions with the extracellular matrix and thus regulates cell adhesion and cell survival. See: J Cell Sci 2000 Jul;113 ( Pt 13):2385-97|
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By Peter D'Adamo. Copyright 2001-2011.