LECSTER LECTIN DATABASE









LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.


Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.



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Total number of records: 619 Matching records: 1

Homo sapiens :
Galectin VIII



Molecular structure of
:Galectin VIII
Homo sapiens


Lecster ID:318 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Galectin VIII
Class:Tandem Repeat S-lectin or galectin
Index Nomenclature:GLTh.Hom .Sap.xx.Xxxx
Characterization Notes:galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. It inhibits adhesion of human carcinoma (1299) cells to plates coated with integrin ligands, and induces cell apoptosis. galectin-8 also interacts with other members of the integrin family, like (alpha)(6)(beta)(1 )integrins. In contrast, galectin-8 only minimally interacts with (alpha)(4 )or (beta)(3 )integrins. We propose that galectin-8 is an integrin binding-protein that interacts to a different extent with several, but not all members of the integrin family. Binding of galectin-8 modulates integrin interactions with the extracellular matrix and thus regulates cell adhesion and cell survival. See: J Cell Sci 2000 Jul;113 ( Pt 13):2385-97
Biological Activity:
Source Tissue:
Specificity:beta-galactoside sugars
Inhibitors:
References:




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2013-6-19: Current Date 9:26:12 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.