LECSTER LECTIN DATABASE










LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.


Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.



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Total number of records: 619 Matching records: 1

Homo sapiens :
Galectin XII



Molecular structure of
:Galectin XII

Homo sapiens



Lecster ID:315 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Galectin XII
Class:S-lectin or galectin
Index Nomenclature:GLTh.Hom.Sap.xx.Xxxx
Characterization Notes:galectin XII contains two domains that are homologous to the galectin CRD. The N-terminal domain contains all the sequence elements predicted to form the two b-sheets found in other galectins, as well as conserved carbohydrate -interacting residues. The C-terminal domain shows considerable divergence from the consensus sequence and many of these conserved residues are not present. Nevertheless, the protein has lactose-binding activity, most likely due to the contribution of the N-terminal domain.
Biological Activity:Ectopic expression of galectin-12 in cancer cells causes cell cycle arrest at the G1 phase and cell growth suppression. See: J Biol Chem 2001 Mar 30
Source Tissue:
Specificity:beta-galactoside sugars
Inhibitors:
References:





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2014-9-2: Current Date 10:12:43 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.