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Molecular structure of
|Lecster ID:315|| Edit Entry |
| Common Nomenclature:||Galectin XII|
|Class:||S-lectin or galectin|
|Characterization Notes:||galectin XII contains two domains that are homologous to the galectin CRD. The N-terminal domain contains all the sequence elements predicted to form the two b-sheets found in other galectins, as well as conserved carbohydrate -interacting residues. The C-terminal domain shows considerable divergence from the consensus sequence and many of these conserved residues are not present. Nevertheless, the protein has lactose-binding activity, most likely due to the contribution of the N-terminal domain.|
|Biological Activity:||Ectopic expression of galectin-12 in cancer cells causes cell cycle arrest at the G1 phase and cell growth suppression. See: J Biol Chem 2001 Mar 30|
2014-3-11: Current Date 10:5:11 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.