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Molecular structure of
|Lecster ID:313|| Edit Entry |
| Common Nomenclature:||L-Selectin (1KJB)|
|Characterization Notes:||L-selectin mediates homing of lymphocytes to lymph nodes (LN). Results suggest that the highly vascularized islet carcinomas are shedding tumor cells into the bloodstream in mice, which is a necessary but insufficient condition for metastasis to occur; L-selectin can facilitate homing of such tumor cells to LN, resulting in metastasis. Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3976-81 Selectins mediate macrophage- and dendrocyte-adhesion to lymphocytes activated by signaling through another C-type lectin, the L-selectin, leading to immunoglobulin-mediated responses. Thus, the functional interplay of MBL, galectins and L-selectin in the acute phase response neutralizes the microbial challenge, and lead to further adaptive immunity. See: Dev Comp Immunol 1999 Jun-Jul;23(4-5):401-20|
|Specificity:||Sulfated forms of sialyl-Le(X) containing Gal-6-SO(4) or GlcNAc-6-SO(4) have been implicated as potential recognition determinants on high endothelial venule ligands for L-selectin. The optimal configuration of sulfate esters on the N-acetyllactosamine (Galbeta1-->4GlcNAc) core of sulfosialyl-Le(X), however, remains unsettled. See: J Biol Chem 2000 Oct 20;275(42):32642-8|
|References:||Biophys. Res. Commun., 216, 1018-1023, 1995|
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