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LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens :

Molecular structure of

Homo sapiens

Lecster ID:300 Edit Entry
Source Organism:
Species:Homo sapiens
Common Nomenclature:Thrombospondin
Index Nomenclature:LECh.Hom.Sap.xx.Xxxx
Characterization Notes:Thrombospondin (TSP) is a glycoprotein secreted from the alpha-granules of platelets upon activation. In the presence of divalent cations, the secreted protein binds to the surface of the activated platelets and is responsible for the endogenous lectin-like activity associated with activated platelets.
Biological Activity:
Source Tissue:
Specificity:Binding of TSP to the platelet surface requires interaction with other platelet surface components in addition to fibrinogen. The observation that fibrinogen only partially inhibits the TSP-mediated agglutination of fixed, activated platelets is consistent with this interpretation.
References:Biochemistry 1985 Jun 18;24(13):3128-34

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By Peter D'Adamo. Copyright 2001-2011.