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Molecular structure of
|Lecster ID:300|| Edit Entry |
| Common Nomenclature:||Thrombospondin|
|Characterization Notes:||Thrombospondin (TSP) is a glycoprotein secreted from the alpha-granules of platelets upon activation. In the presence of divalent cations, the secreted protein binds to the surface of the activated platelets and is responsible for the endogenous lectin-like activity associated with activated platelets.|
|Specificity:||Binding of TSP to the platelet surface requires interaction with other platelet surface components in addition to fibrinogen. The observation that fibrinogen only partially inhibits the TSP-mediated agglutination of fixed, activated platelets is consistent with this interpretation.|
|References:||Biochemistry 1985 Jun 18;24(13):3128-34|
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