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|Homo sapiens : Serum|
Human Mannose Binding Protein (MBP) (1HUP)
Molecular structure of
Serum:Human Mannose Binding Protein (MBP) (1HUP)
|Lecster ID:286|| Edit Entry |
| Common Nomenclature:||Human Mannose Binding Protein (MBP) (1HUP)|
|Characterization Notes:||C-type lectins which are widely present in mammalian plasma.|
|Biological Activity:||In recent years, a 'new' pathway for complement activation mediated by the mannose-binding lectin (MBL) has been described as a key mechanism for the mammalian acute phase response to infection. This complement activation pathway is initiated by a non-self recognition step: the binding of a humoral C-type lectin [mannose-binding lectin (MBL)] to microbial surfaces bearing 'foreign' carbohydrate determinants. The recognition factor, MBL, is associated with a serine protease [MBL-associated serine protease (MASP)] which, upon MBL binding to the microbial ligand, activates the complement component C3, leading to either (a) phagocytosis of the opsonized target via the complement receptor, or (b) humoral cell killing via assembly of the membrane attack complex.See: Dev Comp Immunol 1999 Jun-Jul;23(4-5):401-20|
|References:||Carbohydr Res 1980 Jan 15;78(2):349-63 J Biochem (Tokyo) 1983 Sep;94(3):937-47 Nature Struct. Biol., 1, 789-794, 1994|
2014-10-2: Current Date 5:10:3 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.