LECSTER is the largest, open-access searchable database of lectin characterizations, clinical correlates and citations on the Internet.

Programmed and curated by Peter D'Adamo.

Copyright 2001-2011.

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Total number of records: 619 Matching records: 1

Homo sapiens : Serum
Human Mannose Binding Protein (MBP) (1HUP)

Molecular structure of
Serum:Human Mannose Binding Protein (MBP) (1HUP)

Homo sapiens

Lecster ID:286 Edit Entry
Source Organism:Serum
Species:Homo sapiens
Common Nomenclature:Human Mannose Binding Protein (MBP) (1HUP)
Index Nomenclature:LECh.Hom.Sap.xx.Xxxx
Characterization Notes:C-type lectins which are widely present in mammalian plasma.
Biological Activity:In recent years, a 'new' pathway for complement activation mediated by the mannose-binding lectin (MBL) has been described as a key mechanism for the mammalian acute phase response to infection. This complement activation pathway is initiated by a non-self recognition step: the binding of a humoral C-type lectin [mannose-binding lectin (MBL)] to microbial surfaces bearing 'foreign' carbohydrate determinants. The recognition factor, MBL, is associated with a serine protease [MBL-associated serine protease (MASP)] which, upon MBL binding to the microbial ligand, activates the complement component C3, leading to either (a) phagocytosis of the opsonized target via the complement receptor, or (b) humoral cell killing via assembly of the membrane attack complex.See: Dev Comp Immunol 1999 Jun-Jul;23(4-5):401-20
Source Tissue:
References:Carbohydr Res 1980 Jan 15;78(2):349-63 J Biochem (Tokyo) 1983 Sep;94(3):937-47 Nature Struct. Biol., 1, 789-794, 1994

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2015-1-28: Current Date 4:23:37 GMT: Current Time

By Peter D'Adamo. Copyright 2001-2011.