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Helix pomatia : Roman snail
HPA
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Molecular structure of
Roman snail:HPA
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Helix pomatia
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| Lecster ID:273 | Edit Entry |
| Source Organism: | Roman snail |
| Species: | Helix pomatia |
| Common Nomenclature: | HPA |
| Class: | |
| Index Nomenclature: | LECi.Hel.Pom.xx.Xxxx |
| Characterization Notes: | For discussion of Helix pomatia isolectins, see: Biochim Biophys Acta 1979 Jul 25;579(1):52-61 For binding of psoriatic skin by HPA, see: Z Hautkr 1986 Sep 1;61(17):1241-9 Helix aspersa also contain the same lectin. See: Z Naturforsch [C]. 1985 Mar-Apr;40(3-4):254-61. |
| Biological Activity: | HPA is fairly specific for blood group A antigen. N -acetyl-galactosamine/-glucosamine residues, recognized by HPA, are linked to metastasis in malignant melanoma. In contrast, beta1-6 branched oligosaccharides or sialic acid residues, both of which were correlated with metastasis in other malignancies, are of no functional importance for metastasis formation in malignant melanoma. Thus, HPA proved to be a useful and independent prognostic marker for the metastatic phenotype of melanoma. See: Br J Cancer 2001 Mar 23;84(6):819-23 |
| Source Tissue: | |
| Specificity: | Terminal alpha-N-acetyl-D-galactosaminyl |
| Inhibitors: | |
| References: | Ultrastruct Pathol. 1995 Jan-Feb;19(1):51-9. |
2013-5-18: Current Date 19:5:13 GMT: Current Time
By Peter D'Adamo. Copyright 2001-2011.
