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Datura stramonium : Jimson weed, thorn apple
DSA
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Molecular structure of
Jimson weed, thorn apple:DSA
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Datura stramonium
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| Lecster ID:194 | Edit Entry |
| Source Organism: | Jimson weed, thorn apple |
| Species: | Datura stramonium |
| Common Nomenclature: | DSA |
| Class: | Chitin-bindng lectins |
| Index Nomenclature: | LECp.Dat.Str.se.Hch1 |
| Characterization Notes: | DSA may have a role in cell-cell interactions. The Datura lectins resemble the chitin-binding lectins from Solanum and Lycopersicon. |
| Biological Activity: | DSA is nonspecific in human erythrocyte ABO system. It agglutinates all human erythrocytes equally well. See: 1) The lectin also agglutinates Ehrlich ascites tumor cells and human erythrocytes. See: FEBS Letters 1981 (130); 149-152 DSA induces histamine release from rat peritoneal mast cells. See: General Pharm 1996 (27); 123-128 DSA exerts some anti-nutritive effects. See: Br J Nutrit 1993 (70); 313-321 |
| Source Tissue: | Seeds |
| Specificity: | GlcNAc (oligomers) |
| Inhibitors: | Not inhibited by simple sugars but is inhibited by a partial hydrolysate of chitin-containing mixture of polysaccharides from Aspergillus niger. The inhibitory effectivity of n-acetylglucosamine increases with chain length. See: Arch Biochem Biophys 1984 |
| References: | Biochim Biophys Acta 1978 Jan 25;532(1):92-7 |
2013-6-19: Current Date 23:15:43 GMT: Current Time
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