PATHbase
A database of blood type linked pathology.


DiseaseAuto-immune disease, Systemic lupus erythematosus
Blood Group LinkLupus is most common in type B, and is characterized by inappropriate isohemagglutinin response to stimulation with the B antigen.
Special NoteDrug-induced SLE develops after the use of certain drugs and has symptoms similar to those of SLE. The characteristics of this syndrome are pleuropericardial inflammation, fever, rash, and arthritis. Serologic changes also occur. The clinical and serologic signs usually subside gradually after the offending drug is discontinued. A wide variety of drugs is implicated in this form of SLE.
References1. Stringa SG, Bianchi C, Andrada JA, Comini E, Gaviglio AM, Casala A. Immunologic response to A and B erythrocytic antigen. Arch Dermatol 1976 Apr;112(4):489_92

2. Ottensooser F, Leon N, de Almeida TV. ABO blood groups and isoagglutinins in systemic lupus erythematosus. Rev Bras Pesqui Med Biol 1975 Sep-Dec;8(5-6):421-5.

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