PATHbase
A database of blood type linked pathology.


DiseaseHashimoto's thyroiditis and Graves Disease
Blood Group LinkGroup O have the highest incidence of Hashimoto's thyroiditis of the ABO blood groups. (1) The inability to secrete the water soluble glycoprotein form of the ABO blood group antigens into saliva is significantly more common in patients with Graves' disease than control subjects (40% vs 27%: P less than 0.025) but not among those with Hashimoto's thyroiditis or spontaneous primary atrophic hypothyroidism. Non-secretion is associated with increased susceptibility to infection and to asymptomatic carriage of some microorganisms. Although Yersinia enterocolitica has been found to express antigen cross reactive with the TSH receptor, we did not find an increased prevalence of Yersinia species in the faeces of 107 patients with Graves' disease.
Special Note
References1. D'Adamo P. Unpublished observations.

2. Autoimmunity. 1990;7(4):279-89. Secretor status and infection in patients with Graves' disease. Toft AD, Blackwell CC, Saadi AT, Wu P, Lymberi P, Soudjidelli M, Weir DM.

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