A database of blood type linked pathology.

DiseaseHyperthyroidism (elevated thyroid function)
Blood Group LinkABH non-secretors have a higher incidence of Grave's disease. The inability to secrete the water soluble glycoprotein form of the ABO blood group antigens into saliva is significantly more common in patients with Graves' disease than control subjects (40% versus 27%: p less than 0.025) but not among those with Hashimoto's thyroiditis or spontaneous primary atrophic hypothyroidism. ABH non-secretors with Grave's disease were found to produce higher levels of antitubulin antibodies, while levels of other antibodies were similar to secretors. (1)

Group O has a higher incidence of hyperthyroisism compared to the other ABO groups.Of 162 patients with pernicious anemia whom we studies, 24.1% had clinical thyroid disease; 11.7% were hypothyroid and 8.6% were hyperthyroid. When abnormal serum thyroid-stimulating hormone (TSH) levels were also considered, thyroid disorders existed in 48.3% of 143 patients. Increased or decreased TSH levels as the sole dysfunction occurred in 14.7% and 6.3% of cases, respectively, and were often associated with thyroid antibodies. The high TSH group fits the picture of subclinical hypothyroidism. The nature of the low TSH group remains to be defined. We conclude that TSH screening in patients with pernicious anemia uncovers frequent abnormalities, which are superimposed on a higher coincidence of overt thyroid disease than previously described. Interestingly, also, eight of nine hyperthyroid patients and all seven patients with low TSH levels had blood type O, contrasting significantly with hypothyroid subjects, who more often had blood type A, and with patients without thyroid disorders. (2)
Special Note
References1. Toft AD, Blackwell CC, Saadi AT, et al. Secretor status and infection in patients with Graves' disease. Autoimmunity 1990;7(4):279-89

2. Arch Intern Med 1982 Aug;142(8):1465-1469 Clinical and subclinical thyroid disorders associated with pernicious anemia. Observations on abnormal thyroid-stimulating hormone levels and on a possible association of blood group O with hyperthyroidism. Carmel R, Spencer CA

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