|Blood Group Link||While many risk factors are associated with the development of breast cancer, it is seldom mentioned that blood type has an influence on susceptibility and outcomes. In fact, some researchers have even gone so far as to say that blood groups were shown to possess a predictive value independent of other known prognostic factors when discussing breast cancer. |
Other researchers have actually suggested that a degree of the susceptibility to breast cancer, from a gene perspective, might be a result of a breast cancer-susceptibility locus linked to the ABO locus located on band q34 of chromosome 9.We present evidence of a pedigree in which a major gene for breast cancer-susceptibility appears to segregate in a dominant fashion. Linkage analysis suggests that the breast cancer-susceptibility locus in this family may be linked to the ABO locus, which is located on band q34 of chromosome 9. At an early stage in the analysis, a LOD score of 3.0 for zero recombination was obtained for linkage between ABO and the susceptibility locus, but a single recombinant reduced the LOD score to 1.72 at a recombination fraction of 0.06. A final observation of a nonrecombinant brings the LOD score for this pedigree to 1.99 at theta = 0.05. We attempt to put these results in perspective by discussing the sensitivity of the LOD score to the next observation. Examples of the volatility of LOD scores are given. These simple calculations show that tight linkage represents the worst case for the interpretation of a LOD score of 3.0. Finally, we discuss the linkage between the breast cancer-susceptibility locus and the ABO blood group and approaches to confirming or denying this result. (2)
Research indicates that Blood Type A women are over-represented among breast cancer patients, and that this trend occurs even among women thought to be at low risk for cancer. One of the most significant risk factors for a rapidly progressing breast cancer is also Blood Type A, and Blood Type A women have been observed to have poorer outcomes once they are diagnosed with breast cancer. In complete opposition to these Blood Type A tendencies, we find Blood Type O. Blood type O infers a slight degree of resistance against breast cancer, and even among patients, Blood Type O showed a significantly lower risk of death. Type ABĘs fall nearer to As, having a slight increase in susceptibility and a more dramatic trend towards recurrence and shorter survival times. Blood type B generally behaves a bit more like Blood Type O, imparting a degree of reduced susceptibility or reduced risk. This is particularly evident among women who do not have a family history of breast cancer. However, there are two areas to consider if you are a Blood Type B woman. If you have had a family member with breast cancer, the protection normally associated with being a Type B woman goes out the window, and you need to be more aware of the possibility of breast cancer. Also, if you are a Type B woman, and currently have or have had breast cancer, statistically speaking, your odds of a recurrence of breast cancer tend to be higher. Part of the reason for this is that you tend to survive the original cancer, but nevertheless, you might want to consider some of the long-term immune building and anti-cancer strategies we will discuss.
Breast cancer shows a weaker association with being a non-secretor. Blood group AB is associated with poorer outcomes and earlier death.
The association between blood type A and breast cancer was evaluated in 648 patients with family histories of the disease, 1897 unselected patients, 4577 institutional blood donor controls, and 14,508 extramural blood donor controls. The familial patients were classified into three pedigree groups in which the lifetime breast cancer risks to first-degree relatives ranged from 11% to 32%. In the pedigree group associated with a relatively low risk to relatives, the authors saw a significant excess of blood type A individuals when compared with either control group. The unselected patient population, which was considered to refer to a general series of patients, also showed an excess of blood type A individuals. (1)
|References||1.Cancer 1984 Nov 1;54(9):1845-1849 Blood type A and familial breast cancer. Anderson DE, Haas C|
2. Genet Epidemiol 1984;1(4):363-373 Possible linkage of a breast cancer-susceptibility locus to the ABO locus: sensitivity of LOD scores to a single new recombinant observation. Skolnick MH, Thompson EA, Bishop DT, Cannon LA