Peptic ulcer disease a disease characterized by ulcers or breaks in the inner lining (mucosa) of the stomach or duodenum (region of the small intestine closest to the stomach). The three major causes of peptic ulcer disease are non-steroidal anti-inflammatory drugs (NSAIDS), chronic Heliobacter pylori infection, and states of acid hypersecretion, like Zollinger-Ellison syndrome. |