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The Blood Type Diet Archives Volume 5

ABO and Nitrous Oxide

Posted By: Peter D'Adamo
Date: June-18, 1998 at 09:05:16

This week's Lancet had an interesting letter on differences between ABO groups and the responsiveness of respiratory patients to nitrous oxide (NO) therapy. Apparently, those types with a B antigen (B and AB) have less success with this therapy. The authors speculate that this must be the result of a lack of "anti-B antibody" which perhaps assists the NO in working. They speculate that this might result from "some puntative, unknown gene associated with the ABO locus on chromosome 9Q34."

Well, if you read my post about 2 months ago on ABO and brain stuff, you can call these researchers up and tell them where the gene is that they are looking for. As you will see from the graphic, the red letters pointing to "abo" are overwritten with the letters "ass." The ASS stands not for my critics, but rather for argininosuccinate synthetase, an enzyme which recycles arginine from citrulline in the production of NO. The ABO locus is so close to the ASS locus, that the program wrote one on top of the other!

Some notes from my March lecture in Boston:

* NO is a free radical gas which can diffuse across membranes rapidly, thus acting on neural elements which are at some distance from the site of production.

* One of the modes of action of NO is to stimulate soluble guanylate cyclase, leading to an increase in intracellular cyclic GMP in target cells, and this can then lead to further effects, depending on the cell.

* NO is synthesised from L-arginine by the action of NO synthase (NOS), with the production of L-citrulline.

* L-Citrulline is then recycled to L-arginine by argininosuccinate synthetase and argininosuccinase.

* There is a widespread distribution for NOS within the brain, including in the thalamus and the cerebral cortex, predominantly in neurones but also in astrocytes.

* A diversity of cellular compartments suggests not only that NO may be an active end-product but that, as intermediates may move between compartments, L-arginine and L-citrulline might have a signalling function in their own right. This is speculative, but is supported by the release of arginine upon stimulation of pathways in cerebellar slices and in the thalamus in vivo (Do etal., 1994).

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