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The Blood Type Diet Archives Volume 15

homozygotes (MM,NN) less hypertensive than MN

Posted By: JimB(A1o,Rh+,Secretor,NN--lipid loopy, but unipolar sane)
Date: Friday, 16 February 2001, at 3:20 p.m.

In Response To: Our lipids may go loopy, but we NN's ain't bipolar! (JimB(A1o,Rh+,Secretor,NN--lipid loopy, but unipolar sane))

Balancing what LR4YT says about the advantages of being heterozygous (MN), the homozygous MM and NN types apparently tend to have less hypertension (high blood pressure).

Also from PubMed:

J Hypertens 1984 Aug;2(4):337-41

Blood pressure and blood group markers: association with the MN locus.

Gleiberman L, Gershowitz H, Harburg E, Schork MA

The relationship of blood pressure levels to 12 blood, salivary and serum protein polymorphisms is reported for a sample of 4000+ adult Caucasians from Tecumseh, Michigan. Males with the MN phenotype had significantly higher unadjusted systolic and diastolic blood pressures than those who were homozygous MM or NN. When blood pressure was adjusted for age and weight, males who were Duffy (a-) had higher diastolic pressures than those who were Duffy (a+), and females who were Kidd (b-) had higher diastolic pressures than females who were Kidd (b+). A review of studies reporting on MN- blood pressure associations indicates that six of the eight presented significant findings. These findings, and others from the literature, present evidence that the MN locus (and possibly the Jk locus) actively participates in controlling the response to environmental/dietary stimuli affecting differences in blood pressure. We suggest that the MN blood group be investigated further, particularly vis-a-vis physiological parameters known to be related to blood pressure.

PMID: 6597819

[emphasis added]

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