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The Blood Type Diet Archives Volume 15

Our lipids may go loopy, but we NN's ain't bipolar!

Posted By: JimB(A1o,Rh+,Secretor,NN--lipid loopy, but unipolar sane)
Date: Friday, 16 February 2001, at 2:55 p.m.

In Response To: from PubMed: NN's lipid levels most sensitive to dietary fat (JimB(A1o,Rh+,Secretor,NN))

Also from PubMed:

Biol Psychiatry 1998 Sep 1;44(5):361-3

MN blood groups and bipolar disorder: evidence of genotypic association and Hardy-Weinberg disequilibrium.

Alda M, Grof P, Grof E

Department of Psychiatry, University of Ottawa, Ontario, Canada.

BACKGROUND: MN blood groups have been studied in the past as a genetic marker of biopolar disorder (BD). Several previous studies reported an association of the illness with lower frequency of blood group NN. METHODS: We analyzed distribution of MN blood groups in a sample of 174 patients with BD, 176 with unipolar depression, 98 with schizophrenia, and 331 healthy controls. In addition, we tested whether the inferred genotypes. conform to Hardy-Weinberg equilibrium (HWE). RESULTS: The frequency of NN phenotype was significantly lower among the bipolar patients than in any of the other three groups (p < .001). The genotype frequencies in the BD group deviated significantly from those expected under HWE (p < .01). CONCLUSIONS: These results suggest a possible locus on chromosome 4 (4q28-q31.1) associated with genetic susceptibility to bipolar illness.

PMID: 9755358

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