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The Blood Type Diet Archives Volume 15

Sorry 'bout the biochem but...

Posted By: Stephen (A+)
Date: Thursday, 5 October 2000, at 7:45 a.m.

In Response To: Confused about Peter's DHEA explanation (Rod)

here it is!! This is the reason why DHEA CAN be a problem to cortisol, and won't help ratios always. Supplemental DHEA can increase cortisol. Heres why...

Supplemental DHEA up regulates an enzyme called 3-beta dehydrogenase. This enzyme pushes DHEA through to androstenedione. Big deal huh, but 3-beta dehydrogenase also converts hydroxypregnenolone to hydroxyprogesterone. Now, hydroxyprogesterone (via deoxycortisol) is a precursor to, you guessed it cortisol. This is one reason why DHEA can increase cortisol.

I hope this clears things up.


P.S. There are many natural/nutritional/herbal ways around this without taking DHEA.

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