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The Blood Type Diet Archives Volume 14

Griffonia lectin

Posted By: Peter D'Adamo
Date: Thursday, 27 July 2000, at 3:52 p.m.

In Response To: Help me understand Griffonia (sTeve)

Griffonia lectin has moderate to mild reactivity with both A and B antigen, but more importantly, reacts with Lewis B antigen (a rare occurence). As I've mentioned, Lewis typing can be a 'quick and dirty' way to determine secretor status. Basically, we all start off making Lewis A (unless you are one of the .5% of the world that makes no Lewis antigen, a topic for another post) but secretors convert all their Lewis A antigen into Lewis B, so Non-secretors are Lewis A+ Lewis B- and secretors are Lewis A- Lewis B+.

This Griffonia is more of a problem in Type A and B Secretors, than in A or B Non-secretors.

Why is this important?

Most of the newer type tryptophane supplements ('5HT') are derived from Griffonia.


J Mol Biol 1993 Apr 5;230(3):950-65

Structures of the lectin IV of Griffonia simplicifolia and its complex with the Lewis b human blood group determinant at 2.0 A resolution.

Delbaere LT, Vandonselaar M, Prasad L, Quail JW, Wilson KS, Dauter Z

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