Eat Right 4 Your Type®

Official Website Of Dr. Peter J. D'Adamo & The Blood Type Diet®

View Thread View Post Thread for This Board Read Prev Msg Read Next Msg

The Blood Type Diet Archives Volume 14

Help me understand Griffonia

Posted By: sTeve
Date: Thursday, 27 July 2000, at 1:55 p.m.

Based on the following citation, is Griffonia a Type A/Type B avoid or OK?



Glycobiology 1999 Nov;9(11):1161-70

Related Articles, Books, LinkOut

Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4).

Wu AM, Wu JH, Chen YY, Song SC, Kabat EA

Glyco-Immunochemistry Research Lab, Institute of Molecular and Cellular Biology, Chang-Gung University, Taiwan.

Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4)(GS I-A(4)), which is cytotoxic to the human colon cancer cell lines, is one of two lectin families derived from its seed extract. It contains only a homo-oligomer of subunit A, and is most specific for GalNAcalpha1-->. In order to elucidate the GS I-A(4)-glycoconjugate interactions in greater detail, the combining site of this lectin was further characterized by enzyme linked lectino-sorbent assay (ELLSA) and by inhibition of lectin-glycoprotein interactions.

This study has demonstrated that the Tn-containing glycoproteins tested, consisting of mammalian salivary glycoproteins (armadillo, asialo-hamster sublingual, asialo-ovine, -bovine, and -porcine submandibular), are bound strongly by GS I-A(4.)Among monovalent inhibitors so far tested, p-NO2-phenylalphaGalNAc is the most potent, suggesting that hydrophobic forces are important in the interaction of this lectin. GS I-A(4)is able to accommodate the monosaccharide GalNAc at the nonreducing end of oligosaccharides.

This suggests that the combining site of the lectin is a shallow cavity. Among oligosaccharides and monosaccharides tested as inhibitors of the binding of GS I-A(4), the hierarchy of potencies are:

GalNAcalpha1-->3GalNAcbeta1-->3Galalpha1-->4Galbeta 1-->4Glc (Forssman pentsaccharide) > GalNAcalpha1-->3(LFucalpha1-->2)Gal (blood group A)()> GalNAc > Galalpha1-->4Gal > Galalpha1-->3Gal (blood group B-like)> Gal.

Blood Type Living

Messages in This Thread

View Thread View Post Thread for This Board Read Prev Msg Read Next Msg

Need Help?

Contact D'Adamo Personalized Nutrition customer service for support on where to begin.


Personalized Living

A Daily Webzine Celebrating The Wonder Of Individuality & The Blood Type Diet®

Archive | Signup | Blog

Become a Patient

Center of Excellence in Generative Medicine (COEGM) is Dr. D'Adamo's main clinical facility. To schedule an appointment please visit:

The statements made on our websites have not been evaluated by the FDA (U.S. Food & Drug Administration).
Our products and services are not intended to diagnose, cure or prevent any disease. If a condition persists, please contact your physician.
Copyright © 2015, Hoop-A-Joop, LLC, Inc. All Rights Reserved